The Tennessee Titans will be on the road this week against the Jacksonville Jaguars. They are looking to get back on track after a 19-17 home loss to the Indianapolis Colts. The Titans will walk into this game as favorites, but will they be able to pick up a win?

Here are three bold predictions for Mike Vrabel and his Titans' team.

3. Derrick Henry Runs Wild

Over the last two seasons, the Titans have been led by Derrick Henry. Through two games this season, Henry has rushed for 166 yards and is averaging 4.9 yards per carry. The Titans' offensive line has struggled to begin the season, but Henry has done enough so far to impress.

Against the Jaguars, Henry hits another gear. He has scored six touchdowns against Jacksonville in his career. Most of his damage came in one game. The last time these two teams met, it was in Nashville. Henry carried the ball 17 times for 238 yards and four touchdowns. Who can forget Henry's 99-yard touchdown run down the sideline where he was throwing receivers off him.

Henry will not reach 238 yards in this one, but do not be surprised if he is around 150. Fantasy owners, make sure the bruiser is in your lineup.

2. Titans' Defense Totals Six Sacks

The Titans are tied for second in the league with eight sacks. Cameron Wake and Logan Ryan have been feasting on opposing quarterbacks and that will continue against the Jaguars.

There is drama in Jacksonville with the whole Jalen Ramsey saga that has been going on since their game in Week 2. The Jaguars have given up just five sacks all season. Gardner Minshew has played well and proved that he is mobile and can escape pressure. That will not be the case against the Titans. Minshew will get hit early and often in this game.

1. Titans Win Big

It is hard to go on the road and play on Thursday night. On a short week, it is beneficial to be home, but the Titans will rebound quick against a division rival.

The Titans are coming off a tough loss in their home opener. They will be eager to wipe that bad taste out of their mouths at the expense of the Jaguars. Marcus Mariota will not have to do too much because Henry will be going nuts. The offense will be able to score, but the defense will be the star of the show. This game will be a double-digit score in favor of Tennessee.