Unfortunately, it looks like San Francisco 49ers pass-rusher Nick Bosa is dealing with another injury. 49ers head coach Kyle Shanahan said that Bosa didn't practice Wednesday because of ankle soreness, per Eric Branch of the San Francisco Chronicle.

Bosa was dealing with an ankle injury in the run-up to Week 1, but ended up gutting it out and playing in the opener. It looks like he aggravated the injury during the team's win over the Buccaneers, although it's unclear how badly.

Bosa missed a lot of training camp with the ankle sprain, and he has been unable to stay healthy recently. The second overall pick in April's draft, Bosa missed most of OTAs with a hamstring issue.

Bosa also had tough injury luck in his last year with Ohio State. Last season with the Buckeyes, Bosa was limited to just three games by a core muscle injury that he ended up having surgery on.

San Francisco made upgrading their defense, and specifically the pass-rush, a priority this offseason. The 49ers haven't had a consistent rush in years, so they drafted Bosa and traded for Dee Ford to help remedy that.

In his pro debut, Bosa picked up a sack of Jameis Winston, showing off the potential that had scouts raving about him leading up to the draft. The defense as a whole played well, forcing Winston to throw two pick-sixes.

The brother of Chargers star Joey Bosa, he has all the talent in the world. It looks like staying healthy might be his biggest obstacle in the pros.