San Francisco 49ers offensive stars Deebo Samuel and Elijah Mitchell are expected to give it a go in their NFC West rivalry game against the Arizona Cardinals, according to ESPN's Adam Schefter. However, Schefter reports there are questions about how much they will be able to play, and the 49ers are hoping there aren't any setbacks.

Samuel is dealing with a calf injury, while Mitchell has a rib injury. They both missed a practice during the week and were then limited in the days leading up to the weekend. Samuel and Mitchell are key weapons in Kyle Shanahan's offense, so it would be a blow if they can't play much in this game.

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San Francisco is getting George Kittle back for this game, though, which is huge for Jimmy Garoppolo. The Cardinals are also dealing with their own major injury issues, with signs pointing toward superstars Kyler Murray and DeAndre Hopkins not suiting up. Those two sitting out would give the 49ers a big opportunity to pull off a big win.

San Francisco is trying to salvage its season after a rough start. The 49ers picked up a big win on the road over the Chicago Bears last weekend, and now they're looking to get back to .500 with a win over Arizona.