The Buffalo Bills are looking to move to 5-0 on the 2020 NFL season against the undefeated Tennessee Titans. Unfortunately, they have been dealt a few crucial blows on both sides of the ball. Cornerback Tre'Davious White and wide receiver John Brown have been ruled out versus the Titans, per NFL Network's Tom Pelissero:

According to Jonathan Jones of CBS Sports, the back issue has forced White to miss his first career game due to an injury for the Bills.

Both players had drawn questionable designations heading into Week 5. White opted to test out the back with a pregame workout, however, it appears he will not be able to take part. This will be only the second game that he has missed in his NFL career after sitting out go the 2019 season finale since the Bills had already managed to clinch a spot in the playoffs.

The absence of White leaves yet another notable void for this Buffalo defense to fill since cornerback Levi Wallace was already sidelined. They have since called up cornerbacks Cam Lewis and rookie Dane Jackson from the practice squad to provide some depth. The onus will fall on cornerbacks Josh Norman's veteran experience to serve as a stabilizing factor for the Bills.

With Brown out due to a calf injury, quarterback Josh Allen will need some of his more unproven options to step up in the passing game for the Bills. Although Stefon Diggs is available to lead the receiving corps, it will be interesting to see if rookie Gabriel Davis or Isaiah McKenzie can emerge against the Titans.

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