The Los Angeles Chargers will lose Pro Bowl safety Derwin James for “significant time” again for the second straight season.

James, 24, suffered an injury to his meniscus during the Chargers' practice on Sunday, according to NFL Network's Ian Rapoport.

A stalwart for the Chargers' emerging secondary, James will miss time going into the 2020 NFL regular season after last year only appearing in five games in his sophomore campaign (the last five games of the season). After a breakout debut season in 2018 for the Chargers, which included Pro Bowl and All-Pro selections for the then-rookie, James suffered a stress fracture in his right foot during training camp last year.

The Chargers are set to open the 2020 regular season, alongside neighbor and co-tenant Los Angeles Rams, at newly constructed SoFi Stadium in Inglewood, California. Both Los Angeles clubs are the joint subject of HBO's “Hard Knocks” this year during their respective training camps.

A Florida State product, James was selected with the 17th overall pick in the 2018 NFL Draft by the Chargers. In his spectacular debut season two years ago, James recorded 105 combined tackles, six quarterback hits, 3.5 sacks, three interceptions, and 13 passes deflected, per Pro Football Reference. James was on track to repeat his performance in Year 2 last season if it weren't for the stress fracture appearing this time last year.

Again James will have to start the NFL regular season sidelined for the AFC West franchise, a crushing blow for Los Angeles' secondary and defense.