The Indianapolis Colts are set to take on the Arizona Cardinals in a primetime Christmas Day showdown. Just hours before the contest against the Cardinals, the Colts were hit with a brutal COVID-19 update.

Colts linebacker Darius Leonard, the best defender on the team and one of the better ones in the league, will now miss the contest against the Cardinals.

Leonard, who is reportedly unvaccinated, will now have to miss 10 days of action, essentially forcing him out of both the Cardinals game and the following week's contest against the Las Vegas Raiders.

In addition to Leonard, the Colts placed starting safety Khari Willis and wide receiver Zach Pascal on the reserve/COVID list. It's certainly not ideal news for an Indianapolis team hoping to pick up key ground in the playoff race.

Leonard, the 2018 defensive Rookie of the Year and a two-time All-Pro, had played in over 97 percent of his team's snaps this season. The star defender's absence will be felt against Cardinals star quarterback Kyler Murray, who can really stress a defense with his ability to take off and run.

The Colts will have to dig deep on defense against Murray and the Cardinals without their star and leader, Darius Leonard.