Indianapolis Colts star wide receiver T.Y. Hilton finally made his season debut last weekend in a big win over the Houston Texans. Unfortunately, though, he suffered another injury and was limited in practice this week. As a result, Hilton will be out once again in Week 7 against the San Francisco 49ers. Via Adam Schefter:

This is certainly not ideal for the Colts' offense. Hilton is easily their best wideout and was rather productive against the Texans, collecting four catches for a team-high 80 yards on the day. Hilton missed the first five games of the season due to injury as well before hurting his quad last Sunday. The veteran signed a one-year extension with the organization in March.

Colts head coach Frank Reich did say earlier this week that Hilton had a 50/50 chance of playing, which means the injury can't be too serious. Wideout Parris Campbell also went on the shelf with a serious foot issue and will be sidelined for 2-3 months. Needless to say, Carson Wentz will have limited targets in Week 7 against the Niners.

At 2-4, the Colts desperately need a win but it won't be easy. Week 8's matchup is even more daunting as they face Derrick Henry and the Tennessee Titans. Hopefully, Hilton is back by then.