The Indianapolis Colts are set to play their biggest game of the season in an AFC South showdown with the Houston Texans on Thursday night, so it's a bad time for them to be banged up.

Unfortunately for the Colts, injuries have been something they have been unable to escape all year long.

According to Charean Williams of Pro Football Talk, wide receiver T.Y. Hilton and tight end Eric Ebron are listed as questionable for Indianapolis' Week 12 matchup with Houston.

Hilton is battling a calf injury that has kept him sidelined since Week 9.

Given that Indy is also without Devin Funchess (who has been out since Week 1) and rookie wide out Parris Campbell, who is expected to be on the shelf until December, Hilton's potential absence is more significant than ever.

In the six games he has played this season, Hilton has logged 32 catches for 360 yards and five touchdowns. He has also historically played very well against the Texans, as he has hauled in 82 receptions for 1,519 yards and 10 scores in 15 career games against Houston.

Meanwhile, Ebron is dealing with an ankle issue that does not seem to be nearly as pressing as Hilton's ailment.

Ebron played during the Colts' win over the Jacksonville Jaguars this past Sunday, tallying four grabs for 27 yards. Through 10 games this year, he has caught 27 passes for 331 yards and three touchdowns.

Indianapolis is currently 6-4 and is tied with Houston for first place in the division. However, if the Colts win on Thursday night, they will complete the season sweep of the Texans and guarantee themselves the tiebreaker in the event that both clubs finish with the same record.