Manchester United is set for a difficult matchup over the weekend when they'll take on Tottenham Hotspur at Old Trafford. United are winless in their last three games and will look to bounce back from their humbling defeat at the hands of rivals Manchester City.

In order to earn a win against Antonio Conte and Tottenham, Ralf Rangnick's side will need to push their recent woes behind them and look to take advantage of a mistake-prone Spurs side. Cristiano Ronaldo was unavailable for the derby clash against Manchester City, but expectations are that he'll be able to suit up against Spurs. Of course, he'll play a crucial role for United if they're to earn the crucial win at their home stadium.

United's midfield will need to limit its mistakes, though they will have a far easier time against Spurs than they did against Manchester City. Tottenham lacks a dominating midfielder, especially given Pierre Højbjerg has struggled with form of late. If Paul Pogba and whomever he is paired alongside are able to gain control in the center of the pitch, United will have a far easier time with containing Tottenham.

With all that in mind, here are three bold predictions for the Premier League clash between Manchester United and Tottenham Hotspur, set to kick off at 12:30 PM EST on Saturday, March 12.

3 Bold Predictions for Manchester United vs Tottenham

3. Harry Maguire blunder results in Harry Kane goal

Harry Kane is on his best form of the season right now, and with Manchester United's defensive woes continuing to mount, that could be a dangerous combination. Maguire has been mistake-prone throughout the season, and with Tottenham's lethal counter-attack, he could be susceptible to an error or two at critical moments on Saturday. If anyone in the league is capable of capitalizing on a mistake from a defender, it's Kane, who seems to have an eye for poaching loose balls in the box.

We're predicting a lapse in judgment from Maguire to pay dividends for Spurs and give them a goal, as has occurred far too often for the English defender this season. The captain hasn't been playing all too well, especially in recent weeks, so he could be in for a nightmare outing against Tottenham's capable attackers.

2. Cristiano Ronaldo scores 2 goals in a bounce-back performance

Cristiano Ronaldo has not been the reliable striker the Red Devils were hoping for when they lured him back to Old Trafford this summer. The Portuguese international has scored just 9 goals in 23 games for the club, and has only one goal under his belt in the 2022 calendar year. Those types of numbers are far below his expected production, and he will likely do everything in his power to see one hit the back of the net against Tottenham. With a player of his caliber, it's not wild to imagine that once he sees one go over the line, the goals will come in bunches.

RECOMMENDED (Article Continues Below)

Hence, we think Ronaldo will have a huge game against Spurs, beating Hugo Lloris between the sticks more than once in the game. He'll be playing with an enriched hunger as he hopes to avoid continuing his goal drought, and he should be able to find a gap in Spurs' defense.

1. Manchester United use a late-winner to take 3 points against Tottenham

The two sides match up fairly well for this game, and it should be a close-fought battle throughout the 90 minutes. There's a very good chance this game will be knotted up as we approach the final whistle. If that's the case, United will likely be keener to grab three points rather than settle for a draw, and should look to press the attack. If Tottenham's defense can contain the late-game pressure from Manchester United, the Red Devils could see themselves walking away with a late-winner.

With the likes of Jadon Sancho, Marcus Rashford, Paul Pogba, and Ronaldo more than capable of firing from distance, United could look to a barrage of long shots in order to beat Lloris in the late going, lest they feel they're able to beat Spurs via a cross from the wings. Regardless, the last few minutes of this game should be decisive in the outcome.