It's David vs. Goliath for Week 6 at the Gillette Stadium. With the way things have gone for the New England Patriots, it seems like they'll walk away with another victory against their inter-conference opponents in the New York Giants.

It's hard to place a bet on the Giants when you have the Patriots performing the way they are right now. The offense looks unstoppable with Tom Brady firing at all cylinders, and the defense is as unstoppable as it's ever been. However, they may get hit with a stone to the temple from the little Giants if they aren't careful enough.

Here are three predictions of what will happen in a game, which is New England's game to lose.

Brady will throw for 400 passing yards

Brady remains one of the league's most dominant quarterbacks. Despite being at a mature age of 42, he's still throwing accurate passes to lead the Patriots to lopsided wins. We can expect more of the same passing from one of the greatest quarterbacks when they face the Giants tonight.

The six-time Super Bowl winner has been consistent in the first five weeks, netting 1,409 passing yards and 10 touchdowns. While his completion rate leaves a lot to be desired at 63%, Brady is still a top-quality quarterback who can impose his will at any point in the game.

The Giants' defense isn't the most intimidating in the NFL, so there's no question that Brady can pull off an impressive 400-yard passing game against the Giants. It's more of a challenge for New York to see if they can actually stop Brady from doing what he wants.

The Patriots defense will smother Daniel Jones

The Giants have a brand-new hope in Daniel Jones, but their rookie quarterback will be in for a tough time as he will be up against one of the best defenses in the NFL this season.

The Patriots are a machine on defense, not letting opposing quarterbacks complete 300 passing yards so far this season. They are also effective in rush defense, limiting the run-heavy Washington Redskins to 145 yards.

There are no doubts about the Patriots defense being one of the best. The question lies on whether they'll allow the Giants defense to score at all.

The Giants will surprise the Patriots in the first half

If they can't beat the Patriots, the best hope for the Giants is to pile on as many points in the first half as they can. If they manage to stay on equal footing with the Patriots in the first half, there's no reason they wouldn't be able to have a winning chance late in the game.

Daniel Jones will look to replicate Josh Allen's efforts on offense and throw where it hurts. While his numbers have slowly dipped since his outstanding win against Tampa Bay, he can definitely still throw it. With Saquon Barkley still listed out for Thursday Night Football, he will have to carry the offense on his own.

He'll be able to do that for much of the first half. However, the Patriots should be able to make their adjustments and finish the game on a high note.