The Buffalo Bills will face the Kansas City Chiefs in an AFC Divisional Playoff matchup as the NFL playoffs continue this weekend. It's time to continue our NFL odds series and make a Bills-Chiefs prediction and pick.

The Bills and Chiefs will meet in the postseason for the second consecutive year this weekend as Buffalo will look to avenge their postseason loss a year ago on Sunday. Josh Allen had a big performance in the Bills' Wild Card blow-out win over the New England Patriots.

For more insight on the Bills-Chiefs matchup in the Divisional Round of the 2022 NFL Playoffs, listen below:

Patrick Mahomes ended the season on a good note and the Chiefs kept that momentum rolling with a huge win over the Pittsburgh Steelers on Sunday night. Kansas City is just a slight home favorite in what should be a fantastic game vs. the Bills this weekend.

Here are the odds for Bills-Chiefs AFC Divisional Playoff game, courtesy of FanDuel.

NFL Odds: Bills-Chiefs AFC Divisional Playoff Odds

Buffalo Bills +1.5 (-106)

Kansas City Chiefs -1.5 (-114)

Over 53.5 (-115)

Under 53.5 (-105)

*Watch NFL Games LIVE with fuboTV (click for free trial)

Why The Bills Could Cover The Spread

The Bills have been rolling offensively and may have the best chance of all the AFC teams at keeping pace with the Chiefs. Allen is explosive both through the air and on the ground, using his weapons to give opposing defenses fits. Stefon Diggs is among the biggest matchup problems in the league, while Cole Beasley and the rest of WR corps are no slouches either. The Buffalo defense is tough vs. the pass and could present challenges for the Chiefs on Sunday.

Buffalo vs. the spread

The Bills are 10-6-2 vs. the spread through their 18-game season to this point, covering big time in their win over the Patriots to advance to this game. Buffalo is 5-3 against the spread on the road this season, and 2-1 as road underdogs. One of those wins was in Kansas City earlier this season.

Why The Chiefs Could Cover The Spread

Kansas City will have the home field edge here, which makes it somewhat surprising that they aren't favored by a little bit more. Mahomes' top weapons Tyreek Hill and Travis Kelce are healthy, which often means it may be a long day for the opposing defense. The Chiefs will look to avenge their loss to the Bills earlier season in this one on their way to another AFC Championship game.

RECOMMENDED (Article Continues Below)
GM Brett Veach in the middle, Xavier Worthy, Ruke Orhorhoro, Devontez Walker around him, and Kansas City Chiefs wallpaper in the background

Enzo Flojo ·

Kansas City vs. the spread

The Chiefs went 9-9 vs. the spread during the regular season. They will look to improve on their 5-5 home record against the spread again this week after blowing out the Pittsburgh Steelers in the Wild Card round.

Final Bills-Chiefs AFC Divisional Playoff Prediction & Pick

Take the Chiefs to cover and win at home in this one. Buffalo will present a tough test, but the Chiefs are kings of the AFC until dethroned. Ride with Kansas City to cover and win on their home field in this one, as the spread is very slim.

Final Bills-Chiefs AFC Divisional Playoff Prediction & Pick:  Chiefs -1.5 (-114)

Click here to bet $5, win $150 on any NFL team in the NFL playoffs to win their game (30-1 Odds).

*To claim, new users need to register, make a first-time deposit, and then simply place their first real-money wager on FanDuel Sportsbook on any NFL team playing in the NFL Playoffs to win their matchup. All winning bets will be fulfilled within 72 hours if they win.*