The Indianapolis Colts and San Francisco 49ers will play in an inter-conference matchup on Sunday evening. It's time to continue our NFL odds series and make a Colts-49ers prediction and pick.
The Colts (2-4) and 49ers (2-3) will play on Sunday night, as both teams look to keep pace in the playoff race in their respective conference and division races. Carson Wentz has looked better in recent weeks for Indianapolis, while the 49ers look set to bring Jimmy Garoppolo back as their starting quarterback this week after Trey Lance suffered an injury last week.
Here's how the bookmakers have set the Colts-49ers odds for this Sunday matchup.
NFL Odds: Colts-49ers Odds
Indianapolis Colts +4.5 (-115), +180 ML
San Francisco 49ers -4.5 (-105), -215 ML
Over 42.5 points (-110)
Under 42.5 points (-110)
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Why The Colts Can Cover The Spread
Carson Wentz has actually been a little better than average the past few weeks, and has nine passing touchdowns compared to just one interception this season. Jonathon Taylor has been a flat out beast running the ball and catching it out of the backfield. The Colts defense is a work in progress, but is usually strong when led by a healthy Darius Leonard. The Colts have some key injury questions as well heading into Week 7, as WR T.Y. Hilton and CB Xavier Rhodes are both questionable. The Colts should still be in good shape for a cover, as the 49ers have struggled a bit to start this season and are 4.5-point favorites. The Colts are 4-2 against the spread this season.
Why The 49ers Can Cover The Spread
Kyle Shanahan can always scheme up some easy points. A home, night game is also nice for the 49ers. The 49ers defense has looked suspect at times this season, but looked better last week in a 17-10 loss to the Arizona Cardinals. Deebo Samuel has been a beast at wide receiver so far this season, and could present matchup problems for the Colts if Rhodes is unable to go Sunday night. The 49ers could be in a good spot to get back to .500 at home, though the Colts have been a tough opponent in recent weeks. San Francisco is 1-4 vs. the spread on the young season.
Final Colts-49ers Prediction & Pick
Wentz has been improving each week, and Taylor is a beast in the backfield. Garoppolo might be a bit rusty after a few weeks off, so take the Colts and the points this weekend in San Francisco. The Colts have been a solid offensive team in recent weeks, and their defense could present problems for the 49ers if they are not able to hit plays downfield in the passing game.
FINAL COLTS-49ERS PREDICTION & PICK: Colts +4.5 (-115)
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