New York Giants star running back Saquon Barkley has left Sunday's game against the Chicago Bears with an apparent knee injury.

Barkley was on the ground for some time, slamming the turf in frustration. He was promptly carried off the field.

Schefter later tweeted that Saquon Barkley is getting X-rays on his knee.

Week 2 has already seen a devastating number of injuries to star players and breakout candidates.

San Francisco 49ers star edge-rusher Nick Bosa was carted off the field after suffering an apparent lower-body injury. Indianapolis Colts second-year wideout Parris Campbell was also carted off after suffering an apparent knee injury, and Denver Broncos starting quarterback Drew Lock has gone to the locker room with a shoulder issue.

This has to be immensely frustrating for Saquon Barkley and the Giants, particularly given Barkley's recent injury history.

Saquon was primed for a big sophomore season after leading the NFL in yards from scrimmage in 2018, but he suffered an ankle injury in Week 3 against the Tampa Bay Buccaneers last year.

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While Barkley still rushed for over 1,000 yards and tallied 1,441 yards from scrimmage in 13 games, he seemed to lack some of the explosiveness and fortitude that made him such a star in his rookie campaign.

But Barkley had an offseason to heal up and get back to full strength, and it seemed he would once again be a workhorse for New York's offense.

However, this season has been anything but kind to Barkley. He rushed for a mere six yards on 15 carries in a Week 1 loss to the Pittsburgh Steelers.

There is even more concern on Sunday, with Barkley's status now up in the air after sustaining the knee injury.