With 16 teams left in March Madness it's the Duke Blue Devils that sit as the +325 betting favorites (wager $100 to win $325) on the odds to win the NCAA Tournament at sportsbooks monitored by OddsShark.com.

And that's despite the fact that the Blue Devils are only a No. 2 seed at the Big Dance. Duke, though, gets to face a No. 11 seed in the Midwest Region in the Sweet 16 on Friday in the Syracuse Orange. The Blue Devils are pegged as 11.5-point betting favorites in that matchup, making them by far the biggest chalk in the third round of the NCAA Tournament. The Orange are at the bottom of the futures at +6600 to win the tournament.

If Duke manages to get past Syracuse in the Sweet 16 they'll move on to face either No. 1 Kansas or No. 5 Clemson in the Elite Eight on the weekend. Kansas sits at +850 on the updated odds to win the NCAA Tournament, with Clemson a longer shot at +2500. For Friday's game the Jayhawks are listed as 4.5-point betting favorites.

The other remaining No. 1 seed, the Villanova Wildcats, sits behind Duke at +450 on the tournament odds, as they get set to tip off against No. 5 West Virginia (+1600) on Friday. The other East Region Sweet 16 matchup has No. 2 Purdue (+1600) facing No. 3 Texas Tech (+2200). The Boilermakers are 1.5-point favorites for Friday; Villanova sits as 5.5-point chalk.

The South Region's highest remaining seed is No. 5 Kentucky, and those Wildcats are set at +700 on the updated NCAA Tournament odds and sit listed as 6-point favorites against No. 9 Kansas State (+2800) in their Sweet 16 matchup on Thursday. The other South Region matchup on Thursday has No. 7 Nevada as a slim 1.5-point favorite against No. 11 Loyola-Chicago; they're at +2500 and +5000, respectively, on the latest March Madness futures.

And No. 4 Gonzaga is up against No. 9 Florida State in the West Region on Thursday, with the Bulldogs 5.5-point favorites and tied with Kentucky at +700 on the NCAA Tournament odds; the Seminoles are back at +4000. No. 3 Michigan (+800) takes on No. 7 Texas A&M (+2500) as 3-point betting chalk to round out the Sweet 16 matchups on Thursday.