The Minnesota Twins will host the Chicago White Sox for a three-game set at Target Field set to start on Monday night. It’s time to continue our MLB odds series and make a White Sox-Twins prediction and pick.

The AL Central rivals have had polar opposite seasons through the first three months of the season. Minnesota is currently in last in the AL Central at 34-48. Chicago is currently leading the way in the division with a 49-33 record. The two teams are separated by 14.5 games, and the White Sox will look to bounce back after two losses over the weekend to the Detroit Tigers against a Twins team that has lost five of their last six games.

Here’s how sportsbooks have set the White Sox-Twins odds.

MLB Odds: White Sox-Twins Odds

Chicago White Sox -1.5 (+127)

Minnesota Twins +1.5 (-147)

Over 10 Runs (-114)

Under 10 Runs (-106)

Why The White Sox Could Cover The Spread

The White Sox have been one of the most complete teams in the league this season, which is why this weekend's debacle against Detroit was certainly a fluke. The White Sox gave up 17 runs in two games over the weekend. Jose Abreu did his best to bring his team back on Sunday, and Chicago is hoping that late run will carry over into this series against one of the weakest pitching staffs in baseball.

Chicago's bats have been terrific this season with an average of 5.02 runs per game, which is the fifth-best mark in the majors. Although they are just 18-20 on the road, they average 5.11 runs per game away from home. They allow the seventh-fewest runs in the league, but have fared much worse on the road defensively. They still have a +0.69 run differential in road games to date.

The White Sox will turn to right-hander Dylan Cease in the series opener. Cease has been solid for Chicago with a 7-3 record and 3.75 ERA through 16 starts. His strikeout rate is phenomenal, as the right-hander has fanned 103 batters over 81 2/3 innings of work. Cease has struggled a bit lately with a 4.46 ERA over his last seven starts, but he has bounced back well with two straight quality starts.

Why The Twins Could Cover The Spread

The Twins have been an absolute disaster this season after entering the year with postseason aspirations. The Twins  are now a woeful 34-48 thanks to a 1-5 stretch over their last six games. They allowed a whopping 43 runs over this recent stretch. They have a plethora of key injuries and have shown no sign of turning things around anytime soon.

The Twins have actually been fairly productive at the plate, averaging 4.65 runs per game. That is the 11th-best mark in baseball, and they currently rank seventh in hits per game as well. Their defense, on the other hand, has been downright awful. Minnesota allows 5.43 runs per game, which is the third-worst mark in the majors. They currently have a -0.80 run differential in home games.

Minnesota will turn to right-hander Bailey Ober for the series opener. Ober hasn't been very good with a 0-1 record and 5.84 ERA through six starts. He hasn't made it out of the fourth inning in three straight starts.

It doesn't look good for the Twins in this matchup, but the hope is the bats can carry them.

Final White Sox-Twins Prediction & Pick

There is great value and we should all ride with the White Sox to win this ballgame with confidence. Where do we begin? The disparity in this matchup is clear as day. The White Sox have owned the Twins with a 9-1 record in their last 10 head-to-head matchups coming in. Chicago's run differential is far better than the Twins this season. All signs point to a win for the White Sox, and the fact that we get such a good price is shocking.

FINAL PICK: Chicago White Sox ML (-110)