The Jacksonville Jaguars will take on the Indianapolis Colts in a Week 10 AFC South battle. It's time to continue our NFL odds series and make a Jaguars-Colts prediction and pick.

This game will be a good measuring stick for head coach Urban Meyer's Jaguars. They're coming off of a huge upset win over the Buffalo Bills, a game where they played their best defensive football of the season. It'll be interesting to see how much of that performance they can replicate. Unlike the Jags, the Colts actually have some aspirations of making the playoffs. Indianapolis is still in the thick of the wild card race, so this game against a clearly inferior opponent has to end in a win.

For more insight on the Week 10 matchup between the Jaguars and Colts, listen below:

Here's how the bookmakers have set the odds for the Jaguars-Colts game.

NFL Odds: Jaguars-Colts Odds

Jacksonville Jaguars: +10.5 (-115)

Indianapolis Colts: -10.5 (-105)

Over: 47.5 (-110)

Under: 47.5 (-110)

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Why the Jaguars Could Cover The Spread

Jacksonville produced a shockingly good defensive game in Week 9, and it's not impossible that the same happens in this game. Indianapolis has leaned heavily on the run throughout this entire season, and stopping opposing running games is Jacksonville's strong point on defense. The Jags currently rank as the 12th-best rushing defense in the NFL, as they only allow 103 yards on the ground per game. Jacksonville is also only allowing opposing running backs to average 3.9 yards per carry, one of the best numbers by a defense in the entire NFL.

Despite their reputation as one of the leagues best defenses, the Colts have shown some weaknesses on that side of the ball. Indianapolis is ranked as a bottom ten pass defense in the NFL, allowing 260 passing yards per game. Jacksonville has been far from a prolific passing attack, but they should be able to exploit this weak point in the Indianapolis defense.

Why the Colts Could Cover The Spread

While Jacksonville has defended the run well, the same can't be said about the pass. The Jaguars rank even lower than the Colts in passing yards allowed per game. The Jags allow this much yardage despite facing only 34 pass attempts per game, a number that is one of the lowest in the NFL.  Jacksonville also isn't too intimidating in terms of turnovers, as they have five total takeaways on the season. Colts quarterback Carson Wentz is having a hugely underrated season, and he's more than capable of picking apart this below-average secondary.

Home field advantage will certainly play a big part in this game. The Jags haven't been good at home, but they've been even worse on the road. Jacksonville has played on the road three times this season, and they've scored a combined 48 points in those contests. To make matters even better for the Colts, the Jags allowed a whopping 92 points over their three road games this year. Jacksonville has clearly struggled during their road trips, and it's hard to see this one being any different.

Final Jaguars-Colts Prediction & Pick

Both of these teams have been incredibly unpredictable over the course of the year, so it's hard to confidently pick one side of the spread. Instead, the over is the best pick here. Jacksonville has been bleeding points to anyone they face this season, and the Colts aren't as good of a defense as everyone thinks they are.

Final Jaguars-Colts Prediction & Pick: Over: 47.5 (-110)