We're set for another betting prediction and pick for UFC Vegas 90 as we turn our attention toward this next bout in the Women's Strawweight (115) Division. Venezulea's own Piera Rodriguez will take on UFC veteran Cynthia Calvillo with both fighters trying to bounce back from their last loss. Check out our UFC odds series for our Rodriguez-Calvillo prediction and pick.

Piera Rodriguez (9-1) has gone 2-1 in the UFC so far following her contract win on Dana White's Contender Series. After a strong 2-0 start that saw unanimous decisions over Kay Hansen and Sam Hughes, Rodriguez fell to submission in her last fight and will be looking for redemption as the betting favorite here. Rodriguez stands 5'3″ with a 63.5-inch reach,

Cynthia Calvillo (9-6-1) has gone 6-6-1 in the UFC since 2017. Following her biggest career win over Jessica Eye in 2020, Calvilllo has gone on to lose her last five consecutive fights against some of the best contenders in the division. As she takes a step back here, she'll be hoping to regain her glory and get back to the winning track. Calvillo stands 5'4″ with a 64-inch reach.

Here are the UFC Odds, courtesy of BetOnline. 

UFC Vegas 90 Odds: Piera Rodriguez-Cynthia Calvillo Odds

Piera Rodriguez: -130

Cynthia Calvillo: +110

Over 2.5 rounds: -350

Under 2.5 rounds: +275

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Why Piera Rodriguez Will Win

Piera Rodriguez found her last win against a primary grappler in Sam Hughes via unanimous decision. She started that fight hot out of the gates, but toned down her output as the rounds went on. She spent much of the fight retreating against the advancing Hughes, but she managed to disrupt her rhythm by landing accurate shots on the entries. Calvillo has a similar wrestling-based fight style to Hughes, so Rodriguez could see success here if she's able to fight a similar fight and land her right hand.

Piera Rodriguez is a very active wrestler in her own right with over 3 takedowns per fight. Cynthia Calvillo typically has solid takedown defense, but Rodriguez's aggression through her striking could open opportunities for her to grab a hold of a leg and get this fight to the canvas. As the slight favorite, odds makers are favoring Rodriguez to bounce back from her last loss and capitalize on Calvillo's recent struggles.

Why Cynthia Calvillo Will Win

Following her Main Event win over Jessica Eye back in 2020, Cynthia Calvillo had the Strawweight Division on notice as the next contender at 115 pounds. She was 9-1 at the time and eyeing a title shot if she could get past Katlyn Chookagian in her subsequent bout. She dropped the fight by unanimous decision and hasn't been able to find any luck since, losing four more bouts including an own stoppage from her corner. This will prove to be another crucial fight for Cynthia Calvillo as she tries to get back into the win column.

While her record takes the optical blow, Calvillo's last two fights ended in split decisions and both could have arguably gone her way. She has much more experience than Piera Rodriguez against some of the toughest competition in the weight class, so don't for a second count Calvillo out of this fight. The betting odds are close for a reason and Cynthia Calvillo should surprise some people with how skilled she still is, despite her losing streak.

Final Piera Rodriguez-Cynthia Calvillo Prediction & Pick

The Prelims will continue with this bout between a veteran of the division and a relative newcomer. Both fighters have similar skill sets and will not hesitate to bring this fight to the ground. Cynthia Calvillo has seen action against some of the best strawweights in the world, but will she be able to break out of this current losing skid?

Piera Rodriguez will be the favorite on account of her aggression and ability to stun opponents with her punches. She's also very active in chasing takedowns and she could wear on Calvillo's gas tank throughout this fight. Still, Calvillo is extremely tough and it won't be easy to get her out early in the fight. With the total set where it's at, expect this fight to see the judges' scorecards.

Ultimately, I think this fight favors Cynthia Calvillo the longer it can go and we've seen her have resurgences in the later rounds of fights. If she can withstand the early storm and find success with her wrestling in rounds two and three, she could steal this fight off control time on the ground.

For our prediction, we'll take a shot on the underdog her in Cynthia Calvillo. Piera Rodriguez tends to retreat in the striking and she could have trouble finding the desperation takedown against a strong grappler like Calvillo. While things haven't gone her way recently, I still like Calvillo's output and what she's shown over her last two fights against top competition. Let's roll with the underdog to get the win here.

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Final Piera Rodriguez-Cynthia Calvillo Prediction & Pick: Cynthia Calvillo (+110)