Joe Ryan will take the mound for the Twins to open this interleague series with the Diamondbacks on Tuesday evening. It's time to continue our MLB odds series with a Twins-Diamondbacks prediction and pick.

Twins-Diamondbacks Projected Starters 

Joe Ryan vs. Brandon Pfaadt

Joe Ryan (5-5) with a 3.13 ERA and 0.96 WHIP

Last Start: Joe Ryan allowed one run on six hits and one walk while striking out five batters over six innings in a no-decision against Tampa Bay on Wednesday.

2024 Road Splits: Joe Ryan has been solid both at home and on the road where he is 2-2 with a 2.49 ERA and 0.99 WHIP.

Brandon Pfaadt (3-6) with a 4.37 ERA and 1.18 WHIP

Last Start: Brandon Pfaadt took the loss Wednesday, giving up three runs on five hits and four walks over 6.1 innings as the Diamondbacks fell 3-1 to the Nationals. He failed to strike out a batter.

2024 Home Splits: Brandon Pfaadt has been better at home than on the road with a 2-2 record, 3.41 ERA, and 1.16 WHIP.

Here are the MLB Odds, courtesy of FanDuel. 

MLB Odds: Twins-Diamondbacks Odds

Minnesota Twins: -1.5 (+132)

Moneyline: -126

Arizona Diamondbacks: +1.5 (-160)

Moneyline: +108

Over: 8.5 (+100)

Under: 8.5 (-122)

How to Watch Twins vs. Diamondbacks

Time: 9:40 PM ET/6:40 PM PT

TV: Bally Sports North, MLB Extra Innings

Stream: fuboTV (Click for free trial)

Why The Twins Will Cover The Spread/Win

The Minnesota Twins are poised to secure a victory against the Arizona Diamondbacks on Tuesday night, thanks to a favorable matchup on the road. Joe Ryan, the Twins' right-hander, brings a solid 5-5 record with a 3.13 ERA into the game, showcasing his ability to keep opponents in check. In contrast, Diamondbacks' right-hander Brandon Pfaadt has struggled this season, holding a 3-6 record with a 4.37 ERA.

Ryan's consistency on the mound has been a cornerstone for the Twins this season. His ability to command the strike zone and limit walks has been crucial, as evidenced by his impressive WHIP and strikeout-to-walk ratio. This control will be essential against a Diamondbacks lineup that has shown vulnerability, particularly in their recent series against the Phillies, where they were outscored 16-2 in the final two games.

On the other hand, Pfaadt has had a tumultuous season. Despite flashes of potential, such as his seven-strikeout performance against the Dodgers, he has struggled with consistency and has been prone to giving up runs in key situations. This inconsistency could be exploited by a Twins lineup that has been finding its rhythm, with players like Royce Lewis and Max Kepler stepping up in crucial moments.

The Twins' strong pitching, led by Joe Ryan, and their recent offensive surge make them the favorites to beat Brandon Pfaadt and the Diamondbacks on the road. The combination of Ryan's reliability and the Twins' momentum should see them through to a win on Tuesday night.

Why The Diamondbacks Will Cover The Spread/Win

The Arizona Diamondbacks are set to take on the Minnesota Twins at Chase Field on Tuesday night, and the home team has several reasons to be optimistic about their chances. Brandon Pfaadt, despite his 3-6 record and 4.37 ERA, has shown flashes of brilliance this season that could be pivotal in this matchup against Joe Ryan and the Twins.

Pfaadt's recent performances have been encouraging. He has managed a respectable 1.18 WHIP over 90.2 innings pitched, striking out 84 batters. His ability to limit base runners and generate strikeouts will be crucial against a Twins lineup that has been inconsistent at times. Moreover, Pfaadt has demonstrated resilience and the ability to bounce back from tough outings, which will be essential in a high-stakes game like this one.

The Diamondbacks' offense also provides a significant edge. With a team batting average of .254 and an on-base percentage of .325, Arizona's hitters have been more consistent than their Minnesota counterparts. Players like Ketel Marte, Joc Pederson, and Christian Walker have been instrumental in driving the offense, and their ability to get on base and create scoring opportunities will be key against Joe Ryan, who has been solid but not invincible this season.

The Diamondbacks have been performing well at home, winning four of their last five games. This home-field advantage, combined with their recent form, gives them an edge. While Joe Ryan's consistency on the mound is notable, Brandon Pfaadt's potential to deliver a strong performance, coupled with the Diamondbacks' offensive prowess and home-field advantage, positions Arizona well to secure a victory on Tuesday night. The combination of Pfaadt's resilience and the Diamondbacks' recent momentum should see them through to a win.

Final Twins-Diamondbacks Prediction & Pick

This should be a good matchup on Tuesday night in this series opener in Arizona as the Twins look to kickstart this series with  Arizona with some momentum. It will be Joe Ryan's dominance on the mound that will be the difference maker here as he puts the Diamondbacks in check as they come away with another victory on the road Tuesday night.

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Final Twins-Diamondbacks Prediction & Pick: Minnesota Twins ML (-126), Under 8.5 (-122)