UFC 266 is set to begin on Saturday, September 25 where we have a Heavyweight matchup with major implications. Curtis Blaydes will face off against Jairzinho Rozenstruik, where the winner could be the next in line for a title shot. It's time to continue our UFC odds series with a Curts Blaydes-Jairzinho Rozenstruik prediction and pick.

Blaydes is a well-rounded fighter who goes for the finish in nearly every bout. He's coming off a devastating loss to Derrick Lewis though, so a win will put him back on the path to a shot at the Heavyweight title.

Rozenstruick has been a tad inconsistent in his last five fights, going 3-2 in that span. However, he's been going up against the best the UFC has to offer in the Heavyweight division. A victory on Saturday will give him two in a row, as Rozenstruick continues chasing the belt.

Here's how the sportsbooks have set the UFC 266 odds for this Heavyweight matchup.

UFC 266 odds: Curtis Blaydes-Jairzinho Rozenstruik odds

Curtis Blaydes (-340)

Jairzinho Rozenstruik (+280)

Over 1.5 rounds (-155)

Under 1.5 rounds (+125)

*Watch sports LIVE with fuboTV (Click for free trial)*

How Curtis Blaydes wins the fight

“Razor” likes to keep it on the feet, but has a wrestling background as well. We've seen him take fights to the mat where he can control his opponents and finish the bout with strikes. That's likely Blaydes' game plan for this matchup at UFC 266, as his opponent is more known as a prominent striker. Keeping it on the feet is a dangerous game for Curtis Blaydes here. His wrestling will level the playing field.

Jairzinho Rozenstruik's loss to Ciryl Gane may have created the blueprint for Blaydes to follow. Rozenstruik struggled in the clinch which ultimately led to him losing that fight. Considering Curtis Blaydes can wrestle with the best of them, we should see him get aggressive with his takedown attempts.

How Jairzinho Rozenstruik wins the fight

“Bigi Boy” is one of the best strikers in the Heavyweight division. 11 of his 12 victories have come via KO/TKO, with some of those coming off of UFC legends Andrei Arlovski, Allistair Overeem, and Junior Dos Santos. Rozenstruik will look to add another name to that list on Saturday, as keeping it on the feet will be his game plan against Curtis Blaydes.

He struggled against Ciryl Gane but did bounce back in his last fight with an impressive knockout win. Blaydes has a slight reach advantage, so we should see “Bigi Boy” close the distance and work inside with uppercuts and body shots. He'll need to be careful though to avoid the clinch or any possible takedown attempts. Even so, this fight could end at any moment, making it a must-watch UFC fight.

Curtis Blaydes-Jairzinho Rozenstruik prediction & pick

This is a battle between two monsters in the UFC. Both of these guys throw bombs and this has the potential to be an all-out war. It'll be interesting to see how this one plays out, as both Blaydes and Rozenstruik have everything on the line in this matchup. Even so, Curtis Blaydes has the edge in this fight, as his wrestling background can change the course of this fight. Look for him to be cautious at first, then eventually work the clinch and get a takedown. From there, we should see some vicious ground and pound as Curtis Blaydes earns another career win at UFC 266.

FINAL CURTIS BLAYDES-JAIRZINHO ROZENSTRUIK PICK: Curtis Blaydes wins via KO/TKO in Round 2