The Houston Astros and the Boston Red Sox will play Game 4 of the ALCS Tuesday. It's time to continue our MLB odds series and make an Astros-Red Sox prediction and pick.

The importance of this game is obvious. A win here essentially seals the series for Boston, as a 3-1 lead is a roadblock that is nearly impossible to overcome. A Houston victory means that the Astros are guaranteed to return to their home field in this series, an advantage that can't be understated. The Red Sox ended the season series against Houston with a score of 3-6, but those games are meaningless now. This series is the only one that matters, so expect both teams to play like it.

Here's how the bookmakers have set the odds for Tuesday's game.

MLB Odds: Astros-Red Sox Odds

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Houston Astros ML (+110)

Boston Red Sox ML (-130)

Over 10 runs (-110)

Under 10 runs (-110)

Why the Astros Can Win

Houston came into the postseason with an argument for being the best team in baseball, in large part due to their pitching. The Astros will maintain that pitching advantage in this game when they send out starting pitcher Zack Greinke. While it's true that Greinke didn't have a great end to the regular season, there's still reason to believe that he can put together a nice game in this one. The righty has earned himself some respectable postseason numbers, putting up a 4.18 ERA and a 1.19 WHIP throughout his playoff career. Greinke also only allows a 6.5% barrel percentage, a shockingly low number. The Red Sox barrel the ball up at an extremely high rate as a team, so it's good to see Greinke with that advantage.

Houston's deadly offense has a major advantage over opposing starter Nick Pivetta. Pivetta was mediocre at best over the course of the season, but he ended on a massive cold streak. Over his last seven starts, the righty has posted a 4.97 ERA and a 1.38 WHIP. Pivetta is simply overmatched here, and it's easy to see the Astros delivering a beating when he is on the mound.

Why the Red Sox Can Win

Luckily for Boston, Greinke had a similar end to the season as Pivetta. Over his last seven contests, the former ace allowed an ERA of 6.03 and a WHIP of 1.19. The Red Sox have been on an incredible hot streak, batting .317 as a team over the month of October.  A scorching hot offense and an ice cold pitcher usually combine for quite a few runs, which could be exactly what happens when Greinke takes the hill in Fenway Park Tuesday.

Home field advantage will certainly come into play in this game. The Red Sox have been absolutely deadly at home this postseason earning a .304 batting average to go along with a .370 OBP and a .547 slugging percentage. All of these numbers are elite, and they should stay that way against Greinke, a pitcher who the Red Sox are comfortable facing. The last time Boston played against Greinke, they shelled him for four runs over three innings and handed him a loss.

Final Astros-Red Sox Prediction & Pick

The over is the obvious pick here. Two questionable pitchers are taking the mound, and both offenses have the potential to explode at any moment. Lock in the over with a lot of confidence in this one.

FINAL ASTROS-RED SOX PREDICTION & PICK: Over 10 runs (-110)