The San Francisco 49ers could be without two key offensive weapons in Week 15 for their matchup against the Atlanta Falcons. According to ESPN's Nick Wagoner, both George Kittle and Elijah Mitchell did not practice for the Niners on Wednesday, casting some uncertainty into their playing status for Week 15.

For insight on the 49ers' Week 15 matchup against the Falcons, listen below:

With most Fantasy Football leagues set to get their playoffs underway, the status of Mitchell and Kittle could have huge impacts on first-round matchups. Obviously, both have played a critical role for the Niners, particularly Kittle whose heroics practically lifted the team to a win in Week 14.

Kittle has been dealing with a knee injury, which kept him out of Wednesday's practice, while Mitchell is banged up with both a concussion and a knee issue.

The star tight end has been arguably the best Fantasy Football asset over the past two weeks, having logged video game numbers, including 22 receptions for 332 yards and three touchdowns during the two-game stretch. Mitchell, on the other hand, didn't play in Week 14 while dealing with his injuries, but was productive in his previous two games as well, racking up 199 rushing yards and four touchdowns across that span.

If Kittle can't suit up for the Niners on Sunday, expect Charlie Woerner and Ross Dwelley to see an increase in offensive snaps, though neither would represent a particularly intriguing Fantasy option. Kittle owners in need of a replacement may want to seek out someone like David Njoku, Gerald Everett, or Ricky Seals-Jones as viable options.

As for Mitchell's replacement, the Niners utilized Jeff Wilson Jr. as their lead back in Week 14, logging 13 carries for 56 yards.