Tobias Harris and the Philadelphia 76ers just handed the Los Angeles Lakers their first road loss of the season with a masterful game-winning shot on Wednesday night.

The Sixers star came up big on the last play, as he took on the smaller Alex Caruso on an isolation play before knocking down a pull-up jumper to give Philly the lead with less than three seconds to go. The Lakers couldn't do anything else after that, which resulted in the 107-106 win over the defending champs.

Watch how Harris took over the game on the Sixers' final possession (via TrashTalk):

https://twitter.com/TrashTalk_fr/status/1354631226242572288

The Sixers seemed to have the game in the bag, as they were up by double digits for the majority of the final quarter. Tobias Harris, who ended up with the game's biggest play, put Philly up by as much as 14 with over five minutes left.

From there, the Lakers climbed their way back. After big threes from Alex Caruso, Dennis Schroeder and Kentavious Caldwell-Pope, Anthony Davis knocked down a g0-ahead basket with 10 seconds left on the game clock to cap LA's 13-0 surge.

https://twitter.com/TrashTalk_fr/status/1354630764852342787

This set-up Harris' clutch shot for the Sixers

The 28-year-old swingman finished the game with 24 points on 10-of-16 shooting, while Joel Embiid led the way with 28 points, six rebounds, four assists and two blocks. Ben Simmons also came up big with his third triple-double of the season with a 17-11-10 stat line to help the Sixers' cause.

With the win, Philly is now 10-1 at home while the Lakers, coincidentally, are 10-1 on the road.