The San Francisco 49ers could be down the top wide receiver for the rest of Monday's tilt with the Seattle Seahawks. Midway through the second quarter of the divisional matchup, 49ers wide-out Emmanuel Sanders headed to the locker room with a rib injury.

San Francisco announced that Sanders, 32, is questionable to return to the game. The team also announced that center Weston Richburg (hand) and defensive tackle D.J. Jones (groin) are both questionable to return. The 49ers entered the game without their top pass-catcher in tight end George Kittle, who is out with knee and ankle injuries.

Sanders exited the game with two receptions for 24 yards to his name.

The 49ers acquired Sanders and a 2020 fifth-round selection from the Denver Broncos on Oct. 22 in exchange for a 2020 third- and fourth-round pick. Since then, he has given San Francisco and quarterback Jimmy Garrapollo a true No. 1 option.

On the season, Sanders has 41 receptions for 504 yards and four touchdowns. 11 receptions for 137 yards and two touchdowns have come in two games, entering Monday, with the 49ers. His impressive stat line comes despite tearing his Achilles heel midway through the 2018 season.

With Sanders questionable to return, Kyle Shanahan and Co. will have to get creative with their ability to produce with their wide-outs. Expect, for the rest of the game, for the 49ers to spread the ball around to the likes of Dante Pettis, Marquise Goodwin, Kendrick Bourne and Deebo Samuel. Of course, they will also attempt to tread out yards on the ground — as they have done all season long.