The San Francisco 49ers will be out for revenge during the 2026 season. San Francisco had a magical 2025 campaign, overcoming several major injuries and making it beyond the first round of the playoffs. But they lost to the eventual Super Bowl champions. Now the 49ers are ready to make another run at the Super Bowl with the hope that they can remain relatively healthy.

San Francisco were set to kick off their mandatory minicamp on June 9th. However, head coach Kyle Shanahan had other plans. Shanahan cancelled the team's mandatory minicamp after San Francisco saw perfect attendance at OTAs earlier in the offseason.

That is good news for players who want some more rest to start the summer. But it did rob a few players of making a positive impression before training camp later this summer.

Three 49ers players stand out as being in danger of being cut following the team's cancelled mandatory minicamp.

It's time to admit that the Isaac Guerendo pick did not work out

San Francisco 49ers running back Isaac Guerendo (31) against the Arizona Cardinals at State Farm Stadium.
Mark J. Rebilas-Imagn Images

The 49ers drafted Guerendo in the fourth round of the 2024 NFL Draft.

Guerendo showed some promise as a rookie, logging 84 carries for 420 rushing yards and four touchdowns. But it all went downhill from there.

Guerendo was a healthy scratch throughout the 2025 after falling out of favor with Shanahan. To make matters worse, he tore his pec during a weight lifting session earlier this offseason.

San Francisco already has Christian McCaffrey, Jordan James, and rookie Kaelon Black at the running back position. That trio should be able to handle the workload by themselves. As a result, it could be tempting to cut Guerendo and use his roster spot at a different position.

Put all of that together, and it would not be surprising to see Guerendo's time in San Francisco come to an early end.

Demarcus Robinson may not have a place in San Francisco anymore

San Francisco entered the offseason with a lot of work to do at the wide receiver position. Especially after paying Brandon Aiyuk (more on him later) a boatload of money to basically nothing.

Fortunately, the 49ers aggressively addressed the issue during the offseason.

San Francisco signed Mike Evans to a three-year contract during NFL free agency, giving them a legitimate WR1 even if he is a bit long in the tooth. They also brought in veteran Christian Kirk to give Brock Purdy more options than Evans and third-year year receiver Ricky Pearsall.

The 49ers also used a premium draft pick on De'Zhaun Stribling during the 2026 NFL Draft.

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All of this leaves veteran Demarcus Robinson in a very precarious situation.

Robinson had a disappointing 2025 season, only hauling in 22 receptions for 276 receiving yards and one touchdown. That's a pitiful stat line by itself, but worse when considering how many injuries the 49ers had last fall. He had every opportunity to shine, but couldn't make it happen.

Robinson will turn 32 years old early in the regular season. He is in the final year of his current contract and only carries a $2.70 million cap hit in 2026.

San Francisco may not save a lot of money by cutting Robinson, but they may need his roster spot at another position.

Brandon Aiyuk's feud with San Francisco should end with him being released

San Francisco 49ers wide receiver Brandon Aiyuk (11) looks for yards after the catch against the Minnesota Vikings during the first quarter U.S. Bank Stadium.
Jeffrey Becker-Imagn Images

Obviously, Aiyuk's performance during mandatory minicamp (or lack thereof) has very little to do with his place on this list. Instead, it is his recent feud with the 49ers that has him in danger of being released.

The relationship between Aiyuk and the 49ers came crashing down almost out of nowhere. GM John Lynch confirmed that Aiyuk has probably played his last snaps for the team despite being under contract with a huge salary. It is that salary that could be Aiyuk's undoing.

It all comes down roster bonuses.

Aiyuk's contract features a $24.94 million option bonus that will trigger on September 1st if he is still on the roster. That is a huge amount of money to pay for a player who doesn't seem pleased with the organization to begin with. It must be especially frustrating after San Francisco gave Aiyuk the payday he wanted back in 2024.

This creates a natural deadline for San Francisco to make up their minds about how to handle their disgruntled receiver.

The most reasonable course of action is to cut him, move past the situation, and do the best they can to deal with the financial ramifications.