| May 20 | vs.  | 10:45 PM | SNY | Fenway Park |
| May 21 | vs. | 10:45 PM | MLB Network | Fenway Park |
| May 22 | vs.  | 10:45 PM | MASN | Fenway Park |
| May 23 | vs. | 11:10 PM | MASN | Fenway Park |
| May 24 | vs. | 8:10 PM | MASN | Fenway Park |
| May 25 | vs. | 5:35 PM | MASN | Fenway Park |
| May 26 | @  | 6:10 PM | NESN | American Family Field |
| May 27 | @ | 11:40 PM | NESN | American Family Field |
| May 28 | @ | 5:10 PM | NESN | American Family Field |
| May 30 | @  | 11:15 PM | Apple TV+ | Truist Park |
| May 31 | @ | 8:10 PM | NESN | Truist Park |
| Jun 1 | @ | 5:35 PM | NESN | Truist Park |
| Jun 2 | vs.  | 11:10 PM | FDSW | Fenway Park |
| Jun 3 | vs. | 11:10 PM | FDSW | Fenway Park |
| Jun 4 | vs. | 5:35 PM | FDSW | Fenway Park |
| Jun 6 | @  | 11:05 PM | YES | Yankee Stadium |
| Jun 7 | @ | 11:35 PM | FOX | Yankee Stadium |
| Jun 8 | @ | 5:35 PM | NESN | Yankee Stadium |
| Jun 9 | vs.  | 11:10 PM | FDSSUN | Fenway Park |
| Jun 10 | vs. | 11:10 PM | NESN | Fenway Park |
| Jun 11 | vs. | 11:10 PM | NESN | Fenway Park |
| Jun 13 | vs. | 11:10 PM | NESN | Fenway Park |
| Jun 14 | vs. | 11:15 PM | FOX | Fenway Park |
| Jun 15 | vs. | 5:35 PM | NESN | Fenway Park |
| Jun 17 | @  | 1:40 AM | NESN | T-Mobile Park |
| Jun 18 | @ | 1:40 AM | NESN | T-Mobile Park |
| Jun 18 | @ | 8:10 PM | ROOT Sports NW | T-Mobile Park |
| Jun 21 | @  | 2:15 AM | NBCS-BA | Oracle Park |
| Jun 21 | @ | 8:05 PM | NESN | Oracle Park |
| Jun 22 | @ | 8:05 PM | NESN | Oracle Park |
| Jun 24 | @ | 1:38 AM | NESN | Angel Stadium of Anaheim |
| Jun 25 | @ | 1:38 AM | FDSW | Angel Stadium of Anaheim |
| Jun 25 | @ | 8:07 PM | FDSW | Angel Stadium of Anaheim |
| Jun 27 | vs.  | 11:10 PM | NESN | Fenway Park |
| Jun 28 | vs. | 8:10 PM | NESN | Fenway Park |
| Jun 29 | vs. | 5:35 PM | SNET | Fenway Park |
| Jun 30 | vs.  | 11:10 PM | NESN | Fenway Park |
| Jul 1 | vs. | 11:10 PM | FDSOH | Fenway Park |
| Jul 2 | vs. | 11:10 PM | FDSOH | Fenway Park |
| Jul 4 | @  | 3:05 PM | NESN | Nationals Park |
| Jul 5 | @ | 8:05 PM | MASN | Nationals Park |
| Jul 6 | @ | 5:35 PM | NESN | Nationals Park |
| Jul 7 | vs.  | 11:10 PM | NESN | Fenway Park |
| Jul 8 | vs. | 11:10 PM | COLR | Fenway Park |
| Jul 9 | vs. | 11:10 PM | NESN | Fenway Park |
| Jul 10 | vs. | 11:10 PM | FDSSUN | Fenway Park |
| Jul 11 | vs. | 11:10 PM | NESN | Fenway Park |
| Jul 12 | vs. | 8:10 PM | NESN | Fenway Park |
| Jul 13 | vs. | 5:35 PM | FDSSUN | Fenway Park |
| Jul 18 | @  | 6:20 PM | MARQ | Wrigley Field |
| Jul 19 | @ | 11:15 PM | FOX | Wrigley Field |
| Jul 20 | @ | 6:20 PM | NESN | Wrigley Field |
| Jul 21 | @  | 10:45 PM | NBCS-PH | Citizens Bank Park |
| Jul 22 | @ | 10:45 PM | NBCS-PH | Citizens Bank Park |
| Jul 23 | @ | 11:05 PM | | Citizens Bank Park |
| Jul 25 | vs.  | 11:10 PM | SportsNet LA | Fenway Park |
| Jul 26 | vs. | 11:15 PM | FOX | Fenway Park |
| Jul 27 | vs. | 5:35 PM | NESN | Fenway Park |
| Jul 28 | @  | 11:40 PM | MNNT | Target Field |
| Jul 29 | @ | 11:40 PM | MNNT | Target Field |
| Jul 30 | @ | 5:10 PM | NESN | Target Field |
| Aug 1 | vs.  | 11:10 PM | SCHN | Fenway Park |
| Aug 2 | vs. | 8:10 PM | NESN | Fenway Park |
| Aug 3 | vs. | 3:35 PM | Roku | Fenway Park |
| Aug 4 | vs.  | 11:10 PM | FDSKC | Fenway Park |
| Aug 5 | vs. | 11:10 PM | FDSKC | Fenway Park |
| Aug 6 | vs. | 11:10 PM | FDSKC | Fenway Park |
| Aug 9 | @  | 1:40 AM | NESN | Petco Park |
| Aug 10 | @ | 12:40 AM | NESN | Petco Park |
| Aug 10 | @ | 8:10 PM | SDPA | Petco Park |
| Aug 12 | @ | 12:10 AM | NESN | Minute Maid Park |
| Aug 13 | @ | 12:10 AM | SCHN | Minute Maid Park |
| Aug 13 | @ | 11:10 PM | NESN | Minute Maid Park |
| Aug 15 | vs.  | 11:10 PM | FDSFL | Fenway Park |
| Aug 16 | vs. | 8:10 PM | FDSFL | Fenway Park |
| Aug 17 | vs. | 5:35 PM | FDSFL | Fenway Park |
| Aug 18 | vs. | 11:10 PM | MASN | Fenway Park |
| Aug 19 | vs. | 11:10 PM | NESN | Fenway Park |
| Aug 21 | @ | 11:15 PM | FOX | Yankee Stadium |
| Aug 22 | @ | 11:05 PM | NESN | Yankee Stadium |
| Aug 23 | @ | 5:05 PM | YES | Yankee Stadium |
| Aug 24 | @ | 5:35 PM | NESN | Yankee Stadium |
| Aug 25 | @ | 10:35 PM | NESN | Oriole Park at Camden Yards |
| Aug 26 | @ | 10:35 PM | MASN | Oriole Park at Camden Yards |
| Aug 27 | @ | 10:35 PM | NESN | Oriole Park at Camden Yards |
| Aug 28 | @ | 5:05 PM | NESN | Oriole Park at Camden Yards |
| Aug 29 | vs.  | 11:10 PM | SportsNet PT | Fenway Park |
| Aug 30 | vs. | 8:10 PM | NESN | Fenway Park |
| Aug 31 | vs. | 5:35 PM | NESN | Fenway Park |
| Sep 1 | vs.  | 5:35 PM | CLEG | Fenway Park |
| Sep 2 | vs. | 10:45 PM | NESN | Fenway Park |
| Sep 3 | vs. | 10:45 PM | NESN | Fenway Park |
| Sep 6 | @  | 1:40 AM | ARID | Chase Field |
| Sep 7 | @ | 12:10 AM | NESN | Chase Field |
| Sep 7 | @ | 8:10 PM | NESN | Chase Field |
| Sep 9 | @  | 2:05 AM | NESN | RingCentral Coliseum |
| Sep 10 | @ | 2:05 AM | NBCS-CA | RingCentral Coliseum |
| Sep 10 | @ | 7:35 PM | NBCS-CA | RingCentral Coliseum |
| Sep 12 | vs. | 11:10 PM | NESN | Fenway Park |
| Sep 13 | vs. | 8:10 PM | NESN | Fenway Park |
| Sep 14 | vs. | 5:35 PM | YES | Fenway Park |
| Sep 16 | vs. | 10:45 PM | NBCS-CA | Fenway Park |
| Sep 17 | vs. | 10:45 PM | NBCS-CA | Fenway Park |
| Sep 18 | vs. | 5:35 PM | NBCS-CA | Fenway Park |
| Sep 19 | @ | 11:35 PM | FDSSUN | Tropicana Field |
| Sep 20 | @ | 11:05 PM | FDSSUN | Tropicana Field |
| Sep 21 | @ | 4:10 PM | NESN | Tropicana Field |
| Sep 23 | @ | 11:07 PM | NESN | Rogers Centre |
| Sep 24 | @ | 11:07 PM | NESN | Rogers Centre |
| Sep 25 | @ | 11:07 PM | SNET | Rogers Centre |
| Sep 26 | vs.  | 11:10 PM | FDSDET | Fenway Park |
| Sep 27 | vs. | 8:10 PM | NESN | Fenway Park |
| Sep 28 | vs. | 7:05 PM | NESN | Fenway Park |
