| May 30 | vs.  | 12:10 AM | SCHN | Minute Maid Park |
| May 31 | vs. | 12:10 AM | FDSSUN | Minute Maid Park |
| May 31 | vs. | 8:10 PM | SCHN | Minute Maid Park |
| Jun 1 | vs. | 6:10 PM | SCHN | Minute Maid Park |
| Jun 3 | @  | 10:40 PM | SportsNet PT | PNC Park |
| Jun 4 | @ | 10:40 PM | SCHN | PNC Park |
| Jun 5 | @ | 10:40 PM | SCHN | PNC Park |
| Jun 6 | @  | 11:10 PM | CLEG | Progressive Field |
| Jun 7 | @ | 8:10 PM | SCHN | Progressive Field |
| Jun 8 | @ | 5:40 PM | SCHN | Progressive Field |
| Jun 11 | vs.  | 12:10 AM | SCHN | Minute Maid Park |
| Jun 12 | vs. | 12:10 AM | CHSN | Minute Maid Park |
| Jun 13 | vs. | 12:10 AM | SCHN | Minute Maid Park |
| Jun 14 | vs.  | 12:10 AM | MNNT | Minute Maid Park |
| Jun 14 | vs. | 8:10 PM | MNNT | Minute Maid Park |
| Jun 15 | vs. | 6:10 PM | MNNT | Minute Maid Park |
| Jun 17 | @  | 2:05 AM | SCHN | RingCentral Coliseum |
| Jun 18 | @ | 2:05 AM | NBCS-CA | RingCentral Coliseum |
| Jun 19 | @ | 2:05 AM | SCHN | RingCentral Coliseum |
| Jun 20 | @ | 2:05 AM | SCHN | RingCentral Coliseum |
| Jun 21 | @  | 1:38 AM | SCHN | Angel Stadium of Anaheim |
| Jun 22 | @ | 1:38 AM | FDSW | Angel Stadium of Anaheim |
| Jun 22 | @ | 8:07 PM | FDSW | Angel Stadium of Anaheim |
| Jun 25 | vs.  | 12:10 AM | NBCS-PH | Minute Maid Park |
| Jun 26 | vs. | 12:10 AM | SCHN | Minute Maid Park |
| Jun 26 | vs. | 6:10 PM | SCHN | Minute Maid Park |
| Jun 28 | vs.  | 12:10 AM | MARQ | Minute Maid Park |
| Jun 28 | vs. | 11:15 PM | FOX | Minute Maid Park |
| Jun 29 | vs. | 6:10 PM | SCHN | Minute Maid Park |
| Jul 2 | @  | 12:40 AM | COLR | Coors Field |
| Jul 3 | @ | 12:40 AM | COLR | Coors Field |
| Jul 3 | @ | 7:10 PM | COLR | Coors Field |
| Jul 5 | @  | 1:10 AM | SportsNet LA | Dodger Stadium |
| Jul 5 | @ | 11:15 PM | SportsNet LA | Dodger Stadium |
| Jul 6 | @ | 8:10 PM | SportsNet LA | Dodger Stadium |
| Jul 8 | vs. | 12:10 AM | SCHN | Minute Maid Park |
| Jul 9 | vs. | 12:10 AM | CLEG | Minute Maid Park |
| Jul 10 | vs. | 12:10 AM | SCHN | Minute Maid Park |
| Jul 12 | vs.  | 12:10 AM | CW33 | Minute Maid Park |
| Jul 12 | vs. | 11:35 PM | FOX | Minute Maid Park |
| Jul 13 | vs. | 6:10 PM | SCHN | Minute Maid Park |
| Jul 19 | @  | 2:10 AM | SCHN | T-Mobile Park |
| Jul 20 | @ | 1:40 AM | ROOT Sports NW | T-Mobile Park |
| Jul 20 | @ | 8:10 PM | SCHN | T-Mobile Park |
| Jul 22 | @  | 1:40 AM | ARID | Chase Field |
| Jul 23 | @ | 1:40 AM | SCHN | Chase Field |
| Jul 23 | @ | 7:40 PM | ARID | Chase Field |
| Jul 25 | vs. | 12:10 AM | NBCS-CA | Minute Maid Park |
| Jul 26 | vs. | 12:10 AM | NBCS-CA | Minute Maid Park |
| Jul 26 | vs. | 11:10 PM | SCHN | Minute Maid Park |
| Jul 27 | vs. | 6:10 PM | SCHN | Minute Maid Park |
| Jul 29 | vs.  | 12:10 AM | MASN2 | Minute Maid Park |
| Jul 30 | vs. | 12:10 AM | MASN2 | Minute Maid Park |
| Jul 30 | vs. | 6:10 PM | SCHN | Minute Maid Park |
| Aug 1 | @  | 11:10 PM | SCHN | Fenway Park |
| Aug 2 | @ | 8:10 PM | NESN | Fenway Park |
| Aug 3 | @ | 3:35 PM | Roku | Fenway Park |
| Aug 4 | @  | 10:40 PM | SCHN | LoanDepot Park |
| Aug 5 | @ | 10:40 PM | SCHN | LoanDepot Park |
| Aug 6 | @ | 8:40 PM | FDSFL | LoanDepot Park |
| Aug 8 | @  | 11:05 PM | YES | Yankee Stadium |
| Aug 9 | @ | 6:05 PM | YES | Yankee Stadium |
| Aug 10 | @ | 5:35 PM | SCHN | Yankee Stadium |
| Aug 12 | vs. | 12:10 AM | NESN | Minute Maid Park |
| Aug 13 | vs. | 12:10 AM | SCHN | Minute Maid Park |
| Aug 13 | vs. | 11:10 PM | NESN | Minute Maid Park |
| Aug 16 | vs.  | 12:10 AM | SCHN | Minute Maid Park |
| Aug 16 | vs. | 11:10 PM | SCHN | Minute Maid Park |
| Aug 17 | vs. | 6:10 PM | MASN | Minute Maid Park |
| Aug 18 | @  | 10:40 PM | FDSDET | Comerica Park |
| Aug 19 | @ | 10:40 PM | SCHN | Comerica Park |
| Aug 20 | @ | 5:10 PM | FDSDET | Comerica Park |
| Aug 21 | @ | 11:15 PM | FOX | Oriole Park at Camden Yards |
| Aug 22 | @ | 11:05 PM | SCHN | Oriole Park at Camden Yards |
| Aug 23 | @ | 11:05 PM | MASN | Oriole Park at Camden Yards |
| Aug 24 | @ | 5:35 PM | MASN | Oriole Park at Camden Yards |
| Aug 27 | vs. | 12:10 AM | SCHN | Minute Maid Park |
| Aug 28 | vs. | 12:10 AM | COLR | Minute Maid Park |
| Aug 28 | vs. | 6:10 PM | SCHN | Minute Maid Park |
| Aug 30 | vs. | 12:10 AM | FDSW | Minute Maid Park |
| Aug 30 | vs. | 11:10 PM | SCHN | Minute Maid Park |
| Aug 31 | vs. | 6:10 PM | FDSW | Minute Maid Park |
| Sep 1 | vs. | 6:10 PM | FDSW | Minute Maid Park |
| Sep 3 | vs. | 12:10 AM | YES | Minute Maid Park |
| Sep 4 | vs. | 12:10 AM | Amazon Prime Video | Minute Maid Park |
| Sep 4 | vs. | 11:40 PM | SCHN | Minute Maid Park |
| Sep 6 | @ | 12:05 AM | SCHN | Globe Life Field |
| Sep 6 | @ | 11:15 PM | FOX | Globe Life Field |
| Sep 7 | @ | 6:35 PM | RSN | Globe Life Field |
| Sep 9 | @  | 11:07 PM | SCHN | Rogers Centre |
| Sep 10 | @ | 11:07 PM | SCHN | Rogers Centre |
| Sep 11 | @ | 7:07 PM | SCHN | Rogers Centre |
| Sep 12 | @  | 11:15 PM | FDSSO | Truist Park |
| Sep 13 | @ | 11:15 PM | SCHN | Truist Park |
| Sep 14 | @ | 5:35 PM | SCHN | Truist Park |
| Sep 16 | vs. | 12:10 AM | SCHN | Minute Maid Park |
| Sep 17 | vs. | 12:10 AM | SCHN | Minute Maid Park |
| Sep 18 | vs. | 12:10 AM | SCHN | Minute Maid Park |
| Sep 20 | vs. | 12:10 AM | SCHN | Minute Maid Park |
| Sep 20 | vs. | 11:10 PM | ROOT Sports NW | Minute Maid Park |
| Sep 21 | vs. | 6:10 PM | SCHN | Minute Maid Park |
| Sep 24 | @ | 2:05 AM | SCHN | RingCentral Coliseum |
| Sep 25 | @ | 2:05 AM | SCHN | RingCentral Coliseum |
| Sep 25 | @ | 7:35 PM | SCHN | RingCentral Coliseum |
| Sep 27 | @ | 1:38 AM | SCHN | Angel Stadium of Anaheim |
| Sep 28 | @ | 1:38 AM | SCHN | Angel Stadium of Anaheim |
| Sep 28 | @ | 7:07 PM | SCHN | Angel Stadium of Anaheim |
