| May 25 | @  | 7:10 PM | COLR | Coors Field |
| May 27 | @  | 1:38 AM | MLB Network | Angel Stadium of Anaheim |
| May 28 | @ | 1:38 AM | YES | Angel Stadium of Anaheim |
| May 29 | @ | 1:38 AM | FDSW | Angel Stadium of Anaheim |
| May 31 | @  | 2:10 AM | Apple TV+ | Dodger Stadium |
| May 31 | @ | 11:15 PM | FOX | Dodger Stadium |
| Jun 1 | @ | 11:10 PM | ESPN2 | Dodger Stadium |
| Jun 3 | vs.  | 11:05 PM | YES | Yankee Stadium |
| Jun 4 | vs. | 11:05 PM | Amazon Prime Video | Yankee Stadium |
| Jun 5 | vs. | 11:05 PM | CLEG | Yankee Stadium |
| Jun 6 | vs.  | 11:05 PM | YES | Yankee Stadium |
| Jun 7 | vs. | 11:35 PM | FOX | Yankee Stadium |
| Jun 8 | vs. | 10:30 PM | ESPN | Yankee Stadium |
| Jun 10 | @  | 11:40 PM | YES | Kauffman Stadium |
| Jun 11 | @ | 11:40 PM | Amazon Prime Video | Kauffman Stadium |
| Jun 12 | @ | 11:40 PM | FDSKC | Kauffman Stadium |
| Jun 13 | @ | 11:10 PM | NESN | Fenway Park |
| Jun 14 | @ | 11:15 PM | FOX | Fenway Park |
| Jun 15 | @ | 5:35 PM | NESN | Fenway Park |
| Jun 16 | vs. | 11:05 PM | FDSW | Yankee Stadium |
| Jun 17 | vs. | 11:05 PM | YES | Yankee Stadium |
| Jun 18 | vs. | 11:05 PM | Amazon Prime Video | Yankee Stadium |
| Jun 19 | vs. | 5:05 PM | YES | Yankee Stadium |
| Jun 20 | vs.  | 11:05 PM | YES | Yankee Stadium |
| Jun 21 | vs. | 5:05 PM | MASN | Yankee Stadium |
| Jun 22 | vs. | 3:35 PM | Roku | Yankee Stadium |
| Jun 23 | @  | 11:10 PM | YES | Great American Ballpark |
| Jun 24 | @ | 11:10 PM | FDSOH | Great American Ballpark |
| Jun 25 | @ | 11:10 PM | Amazon Prime Video | Great American Ballpark |
| Jun 27 | vs.  | 11:05 PM | YES | Yankee Stadium |
| Jun 28 | vs. | 5:05 PM | YES | Yankee Stadium |
| Jun 29 | vs. | 5:35 PM | YES | Yankee Stadium |
| Jun 30 | @  | 11:07 PM | SNET | Rogers Centre |
| Jul 1 | @ | 7:07 PM | SNET | Rogers Centre |
| Jul 2 | @ | 11:07 PM | Amazon Prime Video | Rogers Centre |
| Jul 3 | @ | 11:07 PM | YES | Rogers Centre |
| Jul 4 | @  | 7:10 PM | SNY | Citi Field |
| Jul 5 | @ | 8:10 PM | YES | Citi Field |
| Jul 6 | @ | 5:40 PM | SNY | Citi Field |
| Jul 8 | vs.  | 11:05 PM | ROOT Sports NW | Yankee Stadium |
| Jul 9 | vs. | 11:05 PM | Amazon Prime Video | Yankee Stadium |
| Jul 10 | vs. | 11:05 PM | ROOT Sports NW | Yankee Stadium |
| Jul 11 | vs.  | 11:05 PM | MARQ | Yankee Stadium |
| Jul 12 | vs. | 5:05 PM | YES | Yankee Stadium |
| Jul 13 | vs. | 5:35 PM | MARQ | Yankee Stadium |
| Jul 18 | @  | 11:15 PM | FDSSO | Truist Park |
| Jul 19 | @ | 11:15 PM | FDSSO | Truist Park |
| Jul 20 | @ | 5:35 PM | YES | Truist Park |
| Jul 21 | @ | 11:07 PM | SNET | Rogers Centre |
| Jul 22 | @ | 11:07 PM | YES | Rogers Centre |
| Jul 23 | @ | 11:07 PM | Amazon Prime Video | Rogers Centre |
| Jul 25 | vs.  | 11:05 PM | Amazon Prime Video | Yankee Stadium |
| Jul 26 | vs. | 5:05 PM | YES | Yankee Stadium |
| Jul 27 | vs. | 5:35 PM | YES | Yankee Stadium |
| Jul 28 | vs.  | 11:05 PM | YES | Yankee Stadium |
| Jul 29 | vs. | 11:05 PM | YES | Yankee Stadium |
| Jul 30 | vs. | 11:05 PM | FDSSUN | Yankee Stadium |
| Jul 31 | vs. | 5:05 PM | YES | Yankee Stadium |
| Aug 1 | @  | 11:10 PM | YES | LoanDepot Park |
| Aug 2 | @ | 8:10 PM | YES | LoanDepot Park |
| Aug 3 | @ | 5:40 PM | YES | LoanDepot Park |
| Aug 5 | @  | 12:05 AM | RSN | Globe Life Field |
| Aug 6 | @ | 12:05 AM | YES | Globe Life Field |
| Aug 6 | @ | 6:35 PM | RSN | Globe Life Field |
| Aug 8 | vs.  | 11:05 PM | YES | Yankee Stadium |
| Aug 9 | vs. | 6:05 PM | YES | Yankee Stadium |
| Aug 10 | vs. | 5:35 PM | SCHN | Yankee Stadium |
| Aug 11 | vs.  | 11:05 PM | YES | Yankee Stadium |
| Aug 12 | vs. | 11:05 PM | MNNT | Yankee Stadium |
| Aug 13 | vs. | 11:05 PM | Amazon Prime Video | Yankee Stadium |
| Aug 16 | @  | 12:15 AM | FDSMW | Busch Stadium |
| Aug 16 | @ | 11:15 PM | FOX | Busch Stadium |
| Aug 17 | @ | 6:15 PM | YES | Busch Stadium |
| Aug 19 | @ | 11:35 PM | FDSSUN | Tropicana Field |
| Aug 20 | @ | 11:35 PM | YES | Tropicana Field |
| Aug 21 | vs. | 11:15 PM | FOX | Yankee Stadium |
| Aug 22 | vs. | 11:05 PM | NESN | Yankee Stadium |
| Aug 23 | vs. | 5:05 PM | YES | Yankee Stadium |
| Aug 24 | vs. | 5:35 PM | NESN | Yankee Stadium |
| Aug 25 | vs.  | 11:05 PM | YES | Yankee Stadium |
| Aug 26 | vs. | 11:05 PM | MASN2 | Yankee Stadium |
| Aug 27 | vs. | 5:05 PM | MASN | Yankee Stadium |
| Aug 28 | @  | 11:40 PM | CHSN | Guaranteed Rate Field |
| Aug 29 | @ | 11:40 PM | CHSN | Guaranteed Rate Field |
| Aug 30 | @ | 11:10 PM | YES | Guaranteed Rate Field |
| Aug 31 | @ | 6:10 PM | CHSN | Guaranteed Rate Field |
| Sep 3 | @ | 12:10 AM | YES | Minute Maid Park |
| Sep 4 | @ | 12:10 AM | Amazon Prime Video | Minute Maid Park |
| Sep 4 | @ | 11:40 PM | SCHN | Minute Maid Park |
| Sep 5 | vs. | 11:05 PM | YES | Yankee Stadium |
| Sep 6 | vs. | 5:05 PM | YES | Yankee Stadium |
| Sep 7 | vs. | 5:35 PM | YES | Yankee Stadium |
| Sep 9 | vs.  | 11:05 PM | YES | Yankee Stadium |
| Sep 10 | vs. | 11:05 PM | FDSDET | Yankee Stadium |
| Sep 11 | vs. | 11:05 PM | FDSDET | Yankee Stadium |
| Sep 12 | @ | 11:10 PM | NESN | Fenway Park |
| Sep 13 | @ | 8:10 PM | NESN | Fenway Park |
| Sep 14 | @ | 5:35 PM | YES | Fenway Park |
| Sep 15 | @ | 11:40 PM | YES | Target Field |
| Sep 16 | @ | 11:40 PM | YES | Target Field |
| Sep 17 | @ | 11:40 PM | MNNT | Target Field |
| Sep 18 | @ | 11:15 PM | FOX | Oriole Park at Camden Yards |
| Sep 19 | @ | 11:05 PM | MASN | Oriole Park at Camden Yards |
| Sep 20 | @ | 11:05 PM | MASN | Oriole Park at Camden Yards |
| Sep 21 | @ | 5:35 PM | YES | Oriole Park at Camden Yards |
| Sep 23 | vs. | 11:05 PM | YES | Yankee Stadium |
| Sep 24 | vs. | 11:05 PM | CHSN | Yankee Stadium |
| Sep 25 | vs. | 11:05 PM | CHSN | Yankee Stadium |
| Sep 26 | vs. | 11:05 PM | MASN | Yankee Stadium |
| Sep 27 | vs. | 5:05 PM | YES | Yankee Stadium |
| Sep 28 | vs. | 7:05 PM | MASN | Yankee Stadium |
