| Mar 31 | @  | 6:40 PM PST | YES | T-Mobile Park |
| Apr 1 | @ | 6:40 PM PST | TBS | T-Mobile Park |
| Apr 1 | @ | 1:10 PM PST | SEAM | T-Mobile Park |
| Apr 3 | vs.  | 10:35 AM PST | YES | Yankee Stadium |
| Apr 4 | vs. | 4:05 PM PST | MIAM | Yankee Stadium |
| Apr 5 | vs. | 10:35 AM PST | MIAM | Yankee Stadium |
| Apr 7 | vs.  | 4:05 PM PST | YES | Yankee Stadium |
| Apr 8 | vs. | 4:05 PM PST | NBCS-CA | Yankee Stadium |
| Apr 9 | vs. | 10:35 AM PST | NBCS-CA | Yankee Stadium |
| Apr 10 | @  | 4:10 PM PST | YES | Tropicana Field |
| Apr 11 | @ | 3:10 PM PST | YES | Tropicana Field |
| Apr 12 | @ | 10:40 AM PST | YES | Tropicana Field |
| Apr 13 | vs.  | 4:05 PM PST | FDSW | Yankee Stadium |
| Apr 14 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| Apr 15 | vs. | 4:05 PM PST | Amazon Prime Video | Yankee Stadium |
| Apr 16 | vs. | 10:35 AM PST | FDSW | Yankee Stadium |
| Apr 17 | vs.  | 4:05 PM PST | YES | Yankee Stadium |
| Apr 18 | vs. | 10:35 AM PST | ROYL | Yankee Stadium |
| Apr 19 | vs. | 10:35 AM PST | ROYL | Yankee Stadium |
| Apr 21 | @  | 3:45 PM PST | YES | Fenway Park |
| Apr 22 | @ | 3:45 PM PST | MLB Network | Fenway Park |
| Apr 23 | @ | 3:10 PM PST | YES | Fenway Park |
| Apr 25 | @  | 5:10 PM PST | YES | Minute Maid Park |
| Apr 25 | @ | 4:10 PM PST | SCHN | Minute Maid Park |
| Apr 26 | @ | 11:10 AM PST | SCHN | Minute Maid Park |
| Apr 28 | @  | 5:05 PM PST | YES | Globe Life Field |
| Apr 29 | @ | 5:05 PM PST | RSN | Globe Life Field |
| Apr 29 | @ | 11:35 AM PST | RSN | Globe Life Field |
| May 1 | vs.  | 4:05 PM PST | YES | Yankee Stadium |
| May 2 | vs. | 10:35 AM PST | YES | Yankee Stadium |
| May 3 | vs. | 10:35 AM PST | MASN | Yankee Stadium |
| May 4 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| May 5 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| May 6 | vs. | 4:05 PM PST | Amazon Prime Video | Yankee Stadium |
| May 7 | vs. | 9:35 AM PST | RSN | Yankee Stadium |
| May 8 | @  | 4:40 PM PST | YES | American Family Field |
| May 9 | @ | 4:10 PM PST | BREW | American Family Field |
| May 10 | @ | 11:10 AM PST | BREW | American Family Field |
| May 11 | @ | 3:35 PM PST | YES | Oriole Park at Camden Yards |
| May 12 | @ | 3:35 PM PST | MASN | Oriole Park at Camden Yards |
| May 13 | @ | 3:35 PM PST | MASN | Oriole Park at Camden Yards |
| May 15 | @  | 4:15 PM PST | Apple TV+ | Citi Field |
| May 16 | @ | 4:15 PM PST | FOX | Citi Field |
| May 17 | @ | 10:40 AM PST | YES | Citi Field |
| May 18 | vs.  | 4:05 PM PST | YES | Yankee Stadium |
| May 19 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| May 20 | vs. | 4:05 PM PST | SNET | Yankee Stadium |
| May 21 | vs. | 4:05 PM PST | MLB Network | Yankee Stadium |
| May 22 | vs. | 4:05 PM PST | RAYS | Yankee Stadium |
| May 23 | vs. | 10:35 AM PST | RAYS | Yankee Stadium |
| May 24 | vs. | 10:35 AM PST | RAYS | Yankee Stadium |
| May 25 | @ | 12:40 PM PST | ESPN | Kauffman Stadium |
| May 26 | @ | 4:40 PM PST | YES | Kauffman Stadium |
| May 27 | @ | 4:40 PM PST | ROYL | Kauffman Stadium |
| May 30 | @ | 6:40 PM PST | NBCS-CA | RingCentral Coliseum |
| May 31 | @ | 7:05 PM PST | NBCS-CA | RingCentral Coliseum |
| May 31 | @ | 1:05 PM PST | NBCS-CA | RingCentral Coliseum |
| Jun 2 | vs.  | 4:05 PM PST | YES | Yankee Stadium |
| Jun 3 | vs. | 4:05 PM PST | CLEG | Yankee Stadium |
| Jun 4 | vs. | 10:35 AM PST | YES | Yankee Stadium |
| Jun 5 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| Jun 6 | vs. | 4:35 PM PST | FOX | Yankee Stadium |
| Jun 7 | vs. | 10:35 AM PST | YES | Yankee Stadium |
| Jun 8 | @ | 3:40 PM PST | Fox Sports 1 | Progressive Field |
| Jun 9 | @ | 3:40 PM PST | CLEG | Progressive Field |
| Jun 10 | @ | 10:10 AM PST | CLEG | Progressive Field |
| Jun 12 | @ | 4:37 PM PST | YES | Rogers Centre |
| Jun 13 | @ | 12:07 PM PST | YES | Rogers Centre |
| Jun 14 | @ | 10:37 AM PST | SNET | Rogers Centre |
| Jun 16 | vs.  | 4:05 PM PST | YES | Yankee Stadium |
| Jun 17 | vs. | 4:05 PM PST | Amazon Prime Video | Yankee Stadium |
| Jun 18 | vs. | 4:05 PM PST | CHSN | Yankee Stadium |
| Jun 19 | vs.  | 4:05 PM PST | CINR | Yankee Stadium |
| Jun 20 | vs. | 10:35 AM PST | YES | Yankee Stadium |
| Jun 21 | vs. | 10:35 AM PST | YES | Yankee Stadium |
| Jun 22 | @  | 3:40 PM PST | DSN | Comerica Park |
| Jun 23 | @ | 3:40 PM PST | DSN | Comerica Park |
| Jun 24 | @ | 3:40 PM PST | Amazon Prime Video | Comerica Park |
| Jun 25 | @ | 4:10 PM PST | NESN | Fenway Park |
| Jun 26 | @ | 4:10 PM PST | NESN | Fenway Park |
| Jun 27 | @ | 10:10 AM PST | ABC | Fenway Park |
| Jun 28 | @ | 4:20 PM PST | NBC/Peacock | Fenway Park |
| Jun 29 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| Jun 30 | vs. | 4:05 PM PST | TBS | Yankee Stadium |
| Jul 1 | vs. | 10:35 AM PST | DSN | Yankee Stadium |
| Jul 3 | vs.  | 4:05 PM PST | YES | Yankee Stadium |
| Jul 4 | vs. | 10:35 AM PST | MNNT | Yankee Stadium |
| Jul 5 | vs. | 10:35 AM PST | Peacock | Yankee Stadium |
| Jul 6 | @ | 3:40 PM PST | YES | Tropicana Field |
| Jul 7 | @ | 3:40 PM PST | RAYS | Tropicana Field |
| Jul 8 | @ | 3:40 PM PST | Amazon Prime Video | Tropicana Field |
| Jul 9 | @ | 10:10 AM PST | YES | Tropicana Field |
| Jul 10 | @  | 3:45 PM PST | NATS | Nationals Park |
| Jul 11 | @ | 1:05 PM PST | YES | Nationals Park |
| Jul 12 | @ | 10:35 AM PST | NATS | Nationals Park |
| Jul 17 | vs.  | 4:05 PM PST | SportsNet LA | Yankee Stadium |
| Jul 19 | vs. | 5:08 PM PST | FOX | Yankee Stadium |
| Jul 19 | vs. | 4:20 PM PST | NBC/Peacock | Yankee Stadium |
| Jul 20 | vs.  | 4:05 PM PST | SportsNet PT | Yankee Stadium |
| Jul 21 | vs. | 4:05 PM PST | SportsNet PT | Yankee Stadium |
| Jul 22 | vs. | 10:35 AM PST | SportsNet PT | Yankee Stadium |
| Jul 24 | @  | 3:40 PM PST | NBCS-PH | Citizens Bank Park |
| Jul 25 | @ | 3:05 PM PST | YES | Citizens Bank Park |
| Jul 26 | @ | 4:20 PM PST | NBC/Peacock | Citizens Bank Park |
| Jul 27 | @ | 4:40 PM PST | YES | Guaranteed Rate Field |
| Jul 28 | @ | 4:40 PM PST | YES | Guaranteed Rate Field |
| Jul 29 | @ | 4:40 PM PST | CHSN | Guaranteed Rate Field |
| Jul 30 | @ | 11:10 AM PST | YES | Guaranteed Rate Field |
| Jul 31 | @  | 11:20 AM PST | MARQ | Wrigley Field |
| Aug 1 | @ | 4:15 PM PST | FOX | Wrigley Field |
| Aug 2 | @ | 11:20 AM PST | YES | Wrigley Field |
| Aug 3 | vs.  | 4:05 PM PST | CARD | Yankee Stadium |
| Aug 4 | vs. | 4:05 PM PST | CARD | Yankee Stadium |
| Aug 5 | vs. | 4:05 PM PST | CARD | Yankee Stadium |
| Aug 7 | vs.  | 4:05 PM PST | BravesVsn | Yankee Stadium |
| Aug 8 | vs. | 12:05 PM PST | BravesVsn | Yankee Stadium |
| Aug 9 | vs. | 10:35 AM PST | YES | Yankee Stadium |
| Aug 11 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| Aug 12 | vs. | 4:05 PM PST | | Yankee Stadium |
| Aug 13 | vs. | 10:35 AM PST | YES | Yankee Stadium |
| Aug 14 | @ | 4:07 PM PST | YES | Rogers Centre |
| Aug 15 | @ | 12:07 PM PST | YES | Rogers Centre |
| Aug 16 | @ | 10:37 AM PST | SNET | Rogers Centre |
| Aug 18 | @ | 3:35 PM PST | YES | Oriole Park at Camden Yards |
| Aug 19 | @ | 3:35 PM PST | Amazon Prime Video | Oriole Park at Camden Yards |
| Aug 20 | @ | 3:35 PM PST | MASN | Oriole Park at Camden Yards |
| Aug 21 | vs. | 4:05 PM PST | SNET | Yankee Stadium |
| Aug 22 | vs. | 10:35 AM PST | YES | Yankee Stadium |
| Aug 23 | vs. | 10:35 AM PST | SNET | Yankee Stadium |
| Aug 25 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| Aug 26 | vs. | 4:05 PM PST | SCHN | Yankee Stadium |
| Aug 27 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| Aug 28 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| Aug 29 | vs. | 4:15 PM PST | FOX | Yankee Stadium |
| Aug 30 | vs. | 10:35 AM PST | NESN | Yankee Stadium |
| Sep 1 | @ | 6:38 PM PST | YES | Angel Stadium of Anaheim |
| Sep 2 | @ | 6:38 PM PST | FDSW | Angel Stadium of Anaheim |
| Sep 3 | @ | 6:38 PM PST | FDSNW | Angel Stadium of Anaheim |
| Sep 5 | @  | 6:40 PM PST | SDPA | Petco Park |
| Sep 6 | @ | 5:40 PM PST | SDPA | Petco Park |
| Sep 6 | @ | 1:10 PM PST | SDPA | Petco Park |
| Sep 8 | vs.  | 4:05 PM PST | YES | Yankee Stadium |
| Sep 9 | vs. | 4:05 PM PST | Amazon Prime Video | Yankee Stadium |
| Sep 10 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| Sep 11 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| Sep 12 | vs. | 10:35 AM PST | YES | Yankee Stadium |
| Sep 13 | vs. | 10:35 AM PST | YES | Yankee Stadium |
| Sep 14 | @ | 4:40 PM PST | MNNT | Target Field |
| Sep 15 | @ | 4:40 PM PST | MNNT | Target Field |
| Sep 16 | @ | 10:40 AM PST | MNNT | Target Field |
| Sep 19 | @  | 6:40 PM PST | ARID | Chase Field |
| Sep 20 | @ | 5:10 PM PST | ARID | Chase Field |
| Sep 20 | @ | 1:10 PM PST | ARID | Chase Field |
| Sep 22 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| Sep 23 | vs. | 4:05 PM PST | RAYS | Yankee Stadium |
| Sep 24 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| Sep 25 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| Sep 26 | vs. | 4:05 PM PST | YES | Yankee Stadium |
| Sep 27 | vs. | 12:20 PM PST | YES | Yankee Stadium |
