Buffalo Bills 2025 Schedule
Record: (4 - 2)
| Date | Week | Opponent | Result | Broadcast | Venue |
|---|---|---|---|---|---|
| Sep 8 | Week 1 | vs.  | W40-41 | NBC | Highmark Stadium |
| Sep 14 | Week 2 | @  | W30-10 | CBS | MetLife Stadium |
| Sep 19 | Week 3 | vs.  | W21-31 | Amazon Prime Video | Highmark Stadium |
| Sep 28 | Week 4 | vs.  | W19-31 | CBS | Highmark Stadium |
| Oct 6 | Week 5 | vs.  | L23-20 | NBC | Highmark Stadium |
| Oct 13 | Week 6 | @  | L14-24 | ESPN | Mercedes-Benz Stadium |
| Oct 15 | Week 7 | BYE WEEK | |||
| Oct 26 | Week 8 | @  | FOX | Bank of America Stadium | |
| Nov 2 | Week 9 | vs.  | CBS | Highmark Stadium | |
| Nov 9 | Week 10 | @ | CBS | Hard Rock Stadium | |
| Nov 16 | Week 11 | vs.  | CBS | Highmark Stadium | |
| Nov 21 | Week 12 | @  | Amazon Prime Video | NRG Stadium | |
| Nov 30 | Week 13 | @  | CBS | Heinz Field | |
| Dec 7 | Week 14 | vs.  | FOX | Highmark Stadium | |
| Dec 14 | Week 15 | @ | CBS | Gillette Stadium | |
| Dec 21 | Week 16 | @  | CBS | FirstEnergy Stadium | |
| Dec 28 | Week 17 | vs.  | FOX | Highmark Stadium | |
| Jan 4 | Week 18 | vs. | Highmark Stadium |