Cleveland Guardians 2025 Schedule
Date | Opponent | Time | Broadcast | Venue |
|---|---|---|---|---|
| Sep 16 | @  | 10:40 PM | CLEG | Comerica Park |
| Sep 17 | @ | 10:40 PM | FDSDET | Comerica Park |
| Sep 18 | @ | 5:10 PM | CLEG | Comerica Park |
| Sep 20 | @  | 12:10 AM | CLEG | Target Field |
| Sep 20 | @ | 6:10 PM | CLEG | Target Field |
| Sep 20 | @ | 11:10 PM | CLEG | Target Field |
| Sep 21 | @ | 6:10 PM | MNNT | Target Field |
| Sep 23 | vs. | 10:40 PM | CLEG | Progressive Field |
| Sep 24 | vs. | 10:40 PM | FDSDET | Progressive Field |
| Sep 25 | vs. | 10:40 PM | CLEG | Progressive Field |
| Sep 26 | vs.  | 11:10 PM | RSN | Progressive Field |
| Sep 27 | vs. | 10:10 PM | CLEG | Progressive Field |
| Sep 28 | vs. | 7:10 PM | CLEG | Progressive Field |