San Francisco 49ers 2025 Schedule
Date | Opponent | Time | Broadcast | Venue |
|---|---|---|---|---|
| Sep 7 | @  | 8:05 PM | FOX | Lumen Field |
| Sep 14 | @  | 5:00 PM | FOX | Caesars Superdome |
| Sep 21 | vs.  | 8:25 PM | FOX | Levi's Stadium |
| Sep 28 | vs.  | 8:05 PM | FOX | Levi's Stadium |
| Oct 3 | @  | 12:15 AM | Amazon Prime Video | SoFi Stadium |
| Oct 12 | @  | 5:00 PM | CBS | Raymond James Stadium |
| Oct 20 | vs.  | 12:20 AM | NBC | Levi's Stadium |
| Oct 26 | @  | 5:00 PM | FOX | NRG Stadium |
| Nov 2 | @  | 6:00 PM | CBS | MetLife Stadium |
| Nov 9 | vs. | 9:25 PM | FOX | Levi's Stadium |
| Nov 16 | @ | 9:05 PM | FOX | State Farm Stadium |
| Nov 25 | vs.  | 1:15 AM | ESPN | Levi's Stadium |
| Nov 30 | @  | 6:00 PM | CBS | FirstEnergy Stadium |
| Dec 14 | vs.  | 9:25 PM | FOX | Levi's Stadium |
| Dec 23 | @  | 1:15 AM | ESPN | Lucas Oil Stadium |
| Dec 29 | vs.  | 1:20 AM | NBC | Levi's Stadium |
| Jan 4 | vs. | 6:00 PM | Levi's Stadium |