San Francisco 49ers 2025 Schedule
Record: (4 - 1)
| Date | Week | Opponent | Result | Broadcast | Venue |
|---|---|---|---|---|---|
| Sep 7 | Week 1 | @  | W17-13 | FOX | Lumen Field |
| Sep 14 | Week 2 | @  | W26-21 | FOX | Caesars Superdome |
| Sep 21 | Week 3 | vs.  | W15-16 | FOX | Levi's Stadium |
| Sep 28 | Week 4 | vs.  | L26-21 | FOX | Levi's Stadium |
| Oct 3 | Week 5 | @  | Amazon Prime Video | SoFi Stadium | |
| Oct 12 | Week 6 | @  | CBS | Raymond James Stadium | |
| Oct 20 | Week 7 | vs.  | NBC | Levi's Stadium | |
| Oct 26 | Week 8 | @  | FOX | NRG Stadium | |
| Nov 2 | Week 9 | @  | CBS | MetLife Stadium | |
| Nov 9 | Week 10 | vs. | FOX | Levi's Stadium | |
| Nov 16 | Week 11 | @ | FOX | State Farm Stadium | |
| Nov 25 | Week 12 | vs.  | ESPN | Levi's Stadium | |
| Nov 30 | Week 13 | @  | CBS | FirstEnergy Stadium | |
| Dec 3 | Week 14 | BYE WEEK | |||
| Dec 14 | Week 15 | vs.  | FOX | Levi's Stadium | |
| Dec 23 | Week 16 | @  | ESPN | Lucas Oil Stadium | |
| Dec 29 | Week 17 | vs.  | NBC | Levi's Stadium | |
| Jan 4 | Week 18 | vs. | Levi's Stadium |