Arizona Cardinals star wide receiver Larry Fitzgerald will be held out of Sunday's matchup against the New England Patriots after testing positive for COVID-19, according to a report from Mike Garafolo of the NFL Network.

This is obviously a tough blow for the Cardinals, who are currently 6-4 overall and third in the NFC West. Mostly from the slot position, Fitzgerald has received the second-most targets on the team. Only DeAndre Hopkins has more.

With a positive test now, Fitzgerald has been ruled out for Week 12. His status for the following week will be determined by his ability to pass the league's strict protocols. He is now the fifth member of the team to be placed on the COVID-19 list. Others who have been on this list include receiver KeeSean Johnson, linebacker Devon Kennard and cornerback Byron Murphy.

Earlier this week, the Cardinals placed safety Deionte Thompson on the COVID-19 list.

With Fitzgerald ruled out, second-year wide receiver Andy Isabella will likely assume the slot position. This shouldn't be much of an issue, as Isabella is familiar with playing in this position. According to rotoworld.com, he's played in the slot on 86 percent of his snaps this season.

In his 10 appearances this season, Fitzgerald has 43 receptions for 336 yards. Unfortunately, he has zero touchdowns to his credit in this campaign.

The Cardinals and Patriots will meet on Sunday. Kick-off inside Gillette Stadium is set for 1:00 p.m. ET, with FOX having live broadcast coverage.