The Arizona Diamondbacks and the San Diego Padres will battle it out for the fourth and final time of this opening series. San Diego will be looking to complete the dominant sweep of Arizona after defeating the Diamondbacks 7-0 just last night. Despite a rough Spring Training, the Padres entered the 2021 season as the second most likely team to win the World Series. Behind superstars Fernando Tatis, Jr. and Manny Machado, this Padre team is looking like a real force to be reckoned with. It’s time to continue our MLB odds series and make a Diamondbacks-Padres prediction and pick.

Here’s how sportsbooks have set the opening Diamondbacks-Padres odds.

MLB Odds: Diamondbacks-Padres Odds

Arizona Diamondbacks +1.5 (-105)

San Diego Padres -1.5 (-115)

Over 9 Runs (-115)

Under 9 Runs (-105)

Why The Diamondbacks Could Cover The Spread

The Arizona Diamondbacks are in one of the toughest divisions in baseball and have to see the Padres more times than they'd certainly like to. In order to find success in 2021, Arizona will have to find a way to win some games against San Diego and Los Angeles. After losing the first three in this series, the fourth and final leg will be critical for the Diamondbacks. Arizona looked solid in the opener, plating seven in a one-run loss. The bats have since cooled off with just two runs in the last two games.

There have been some real bright spots in this lineup through the first three games. Ketel Marte is a star in the making and has started off scorching for his club. He has delivered three-straight multi-hit games to open the year. Arizona has also seen surprising contributions from Asdrubel Cabrera, who is 3 for 8 on the young season with a home run and three RBI. The Diamondbacks will need these guys to stay hot in order to give Taylor Widener a chance to get a win in his first career start. Widener has seen some success as a reliever against these same Padres as San Diego players have hit just .125 against him.

Why The Padres Could Cover The Spread

The San Diego Padres have had a historic start to what could be a fantastic 2021 season. This is just the fourth time in franchise history that San Diego has started the year on a three-game winning streak. They will hope to close out a sweep of the Diamondbacks and tie the record for the best start in Padre history. San Diego is locked and loaded behind one of the league's best lineups and a revamped pitching staff. Padre hitters have found a ton of success in the series thus far.

Eric Hosmer is having a year! He set a team record with 13 total bases in his first two games of the season. Hosmer has delivered back-to-back three-hit games with two home runs and six RBI. Manny Machado and Wil Meyers have also started the year hot as well. Machado went 3-4 with a homer and Meyers had two doubles and three RBI in the 7-0 win on Saturday night. They will look to stay hot and provide nice run support for their starting pitcher, Chris Paddack. Paddack is making his fourth career start against Arizona. He is 2-1 with a 1.59 ERA in 18.1 innings against the Diamondbacks.

Final Diamondbacks-Padres Prediction & Pick

The San Diego Padres are the most exciting team to watch in Major League Baseball. They possess a ton of pop and have the ability to score at least five runs in every game. Don't be surprised if they finish the year with the highest runs-per-game average in the league. They will be in a tight division race with the Dodgers and have to know the importance of taking every game against the rest of the NL West. San Diego will win this one big behind a gem from right-hander Chris Paddack.

FINAL PICK: San Diego Padres -1.5 (-115)