New Orleans Saints quarterback Drew Brees is expected to be out of commission for at least two weeks due to the chest injuries he sustained in his team’s Week 10 victory over the San Francisco 49ers, according to a report from Ian Rapoport of the NFL Network.

As Rapoport noted in his tweet, Brees suffered fractured ribs and a collapsed lung. The former Purdue Boilermaker sought a second opinion on his injuries, but there was no change in the initial results. He’ll be re-evaluated in roughly two weeks. If he’s placed in the injured reserve list, he’ll miss at least three games.

Interestingly, Saints head coach Sean Payton has yet to name his starting quarterback for Week 11. Still, most analysts believe it will be Jameis Winston getting the nod against the Atlanta Falcons.

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Brees completed eight of his 13 passes against the 49ers, racking up 76 yards and one touchdown. Alvin Kamara led the Saints in receptions with seven for 83 yards and one touchdown.

Clearly, this is a tough blow for the Saints. At 7-2 overall and 1st in the NFC South, they’re a team that is firmly in the playoff hunt. Will the loss of Brees lead to a stretch of uncertainty, or will Winston be able to step up to the challenge?

The Saints will be back in action on November 22, when they’ll serve as hosts to the Falcons. Kick-off is set for 1:00 p.m. ET, with FOX having live broadcast coverage.

Let’s see how the Saints perform without their championship-winning leader.