The West Virginia Mountaineers and the Oklahoma Sooners will face off in one of the best games of Week 4 of college football. It's time to continue our college football odds series and make a West Virginia-Oklahoma prediction and pick.

West Virginia certainly has momentum on their side heading into this matchup. The Mountaineers beat the ranked Virginia Tech Hokies at home, giving themselves their best win of the year. This game against Oklahoma is easily their toughest test of the entire year, so a good performance here will be a huge boost to West Virginia's confidence. The Sooners would rather forget their last game, as it was another sluggish performance from them. Oklahoma allowed the Nebraska Cornhuskers to hang around for three and a half quarters before finally putting the game away. This should be a good one, so let's get into the pick.

Here's how the bookmakers have set the odds for Saturday's game.

CFB Odds: West Virginia-Oklahoma Odds

West Virginia Mountaineers +16 (-110)

Oklahoma Sooners -16 (-110)

Over 57 1/2 points (-110)

Under 57 1/2 points (-110)

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Why West Virginia Could Cover The Spread

The Mountaineers have been one of the more efficient offenses this season. They average 5.5 yards per play and 25 points per game, two solid numbers. Quarterback Jarret Doege has been solid, and running back Leddie Brown has been one of the best running backs in college football. The offensive line is playing at a high level too. This is an offense that doesn't have many holes, and they should be able to hold their own against a suspect Oklahoma defense that struggled against Tulane in the first week of the season.

Oklahoma quarterback Spencer Rattler entered the season as the favorite for the Heisman trophy. He hasn't come close to living up to that billing. Rattler has been plagued by poor decision-making and some inconsistent ball placement. The sophomore starter struggled against Tulane and Nebraska, with his only good game coming against the abysmal Western Carolina Catamounts. Rattler still hasn't played well against a real defense, so there's a good chance that he struggles against West Virginia in this contest.

Why Oklahoma Could Cover The Spread

Surprisingly, the Sooners have been a good defensive team throughout their first three games. Their pass defense is hovering just around average, but Oklahoma has been great against the run. Defensive coordinator Alex Grinch's unit has allowed only 2.8 yards per carry this season while also only allowing 97 rushing yards per game. West Virginia's entire offensive game plan is built around being able to run the football, and they won't be able to do that easily here. Expect Oklahoma's defense to fare well against the Mountaineers on defense in this one.

While West Virginia's defense has been decent, they haven't faced a team that's as good as Oklahoma. The Sooners have one of the best receiving corps in football with Jadon Haselwood, Theo Wease, and Marvin Mims. Kennedy Brooks leads one of the better rushing attacks in the nation. The Mountaineers gave up 31 points to Maryland and 21 to Virginia Tech, two offenses that can't compare to Oklahoma's. Rattler may struggle to settle in, but this shouldn't be a particularly tough game for him.

Final West Virginia-Oklahoma Prediction & Pick

This is a huge spread, but Oklahoma is still the right pick. We're yet to see what the Mountaineers look like on offense when the run game isn't working to perfection, but we should find out here. Playing in Norman will be too much for Jarret Doege, and the Sooners will walk away with a huge victory.

FINAL PICK: Oklahoma Sooners -16 (-110)