Week 6 presents an intriguing landscape for wide receiver decisions in fantasy football. With the Texans and Vikings on bye, managers are missing elite options like Justin Jefferson and Nico Collins, creating opportunities for lesser-known players to shine. The key this week is identifying receivers with favorable matchups while avoiding the obvious chalk plays that everyone else is starting. Here are the strategic wide receiver moves that can give you a competitive edge in your fantasy leagues.
Start 'em Wide Receivers in Fantasy Football Week 6

Tetairoa McMillan, Carolina Panthers (vs. Dallas Cowboys)
The rookie receiver has quietly established himself as Carolina's clear WR1 with consistent target volume that makes him matchup-proof. McMillan has seen eight or more targets in every single game this season, accumulating a 23% target share and 42% air yards share. Against Dallas, he faces a Cowboys defense that has been torched through the air, allowing 1,423 passing yards (most in the NFL) and struggling particularly against outside receivers. The Cowboys' secondary issues are compounded by potential absences of key defensive players like Micah Parsons and DeMarcus Lawrence. With Carolina likely playing from behind, expect heavy passing volume that benefits McMillan's consistent target floor.
Jaylen Waddle, Miami Dolphins (vs. Los Angeles Chargers)
Waddle is primed for a massive Week 6 performance with Tyreek Hill sidelined and Tua Tagovailoa looking his way consistently. In Week 5 without Hill, Waddle caught six passes for 110 yards and one touchdown, demonstrating his ability to handle WR1 duties. The Chargers defense, while improved, has shown vulnerability to slot receivers and underneath routes where Waddle excels. Miami's offensive coordinator will likely design quick-hitting plays to get Waddle the ball in space, making him an excellent play in both standard and PPR formats. The Dolphins' offensive line struggles mean short passes to Waddle will be essential.
Xavier Worthy, Kansas City Chiefs (vs. Detroit Lions)
Despite dealing with shoulder and ankle injuries that had him questionable, Worthy presents significant upside in what should be a high-scoring affair against Detroit. The Lions defense has been generous to opposing receivers, particularly in the slot where Worthy operates effectively. Kansas City's offense has been searching for consistent receiving options beyond Travis Kelce, and Worthy's speed creates mismatches that Detroit's linebacker corps struggles to handle. With the game likely to feature multiple lead changes, expect Andy Reid to dial up designed touches for Worthy in space. His week-winning ceiling makes him worth the injury risk in tournaments and deeper leagues.
Sit 'em Wide Receivers in Fantasy Football Week 6

Garrett Wilson, New York Jets (vs. Denver Broncos)
Wilson faces the league's most fearsome pass rush in Denver, which leads the NFL with 21 sacks through five games and boasts the highest pressure rate. The Broncos defense has been particularly effective at limiting opposing receivers, and Justin Fields has struggled with pocket presence when under duress. Denver's secondary, led by Patrick Surtain II, has the talent to shadow Wilson and limit his big-play opportunities. The Jets' offensive line has been inconsistent in protection, which could lead to a short passing game that doesn't favor Wilson's downfield skill set. In a potential low-scoring defensive struggle, Wilson's ceiling is capped significantly.
Chris Olave, New Orleans Saints (vs. New England Patriots)
While Olave remains talented, the Saints' offensive inconsistencies make him a risky play despite a seemingly favorable matchup. New Orleans has struggled with quarterback play and offensive line protection, limiting their ability to consistently move the ball downfield where Olave thrives. The Patriots defense, while not elite, has shown improvement in recent weeks and should be well-prepared coming off their bye week. Olave's target share has been inconsistent, and the Saints' tendency toward conservative game scripts limits his explosive play potential. In a game with a relatively low total, Olave lacks the target volume floor needed for reliable fantasy production.
George Pickens, Dallas Cowboys (at Carolina Panthers)
Pickens' mercurial nature and Dallas's offensive identity make him an unreliable fantasy option despite facing Carolina's vulnerable pass defense. The Cowboys have shown they can win games through their ground attack and short passing game, potentially limiting Pickens' target opportunities. His route-running precision has been questioned, and Dak Prescott has shown preference for more reliable targets like Jake Ferguson and Ryan Flournoy in crucial situations. Carolina's defense, while poor overall, has actually been more stout against outside receivers than slot options. Pickens' boom-or-bust profile makes him too volatile for consistent lineup construction.
Sleeper Wide Receivers in Fantasy Football Week 6

Ryan Flournoy, Dallas Cowboys (at Carolina Panthers)
The second-year receiver burst onto the scene in Week 5 with six catches for 114 yards on nine targets, immediately establishing himself as Dak Prescott's preferred downfield option. With CeeDee Lamb and KaVontae Turpin both dealing with injuries, Flournoy has carved out a significant role in Dallas's aerial attack. Carolina's defense ranks near the bottom against outside receivers, and the Panthers' tendency to allow big plays through the air creates an ideal environment for Flournoy's skill set. His rapport with Prescott appears genuine, and Dallas's offensive coordinator has shown willingness to feature him in key situations. Available in most leagues, Flournoy represents excellent value with WR2 upside.
Kendrick Bourne, San Francisco 49ers (at Tampa Bay Buccaneers)
Bourne exploded for 10 catches and 142 yards against the Rams in Week 5, showcasing his chemistry with Mac Jones when given significant opportunities. With Ricky Pearsall and Jauan Jennings potentially sidelined again due to injuries, Bourne figures to maintain a prominent role in San Francisco's passing attack. Tampa Bay's defense has struggled against slot receivers and possession-style players, making this an ideal matchup for Bourne's skill set. The 49ers may need to throw more than usual if Brock Purdy remains limited, creating additional target opportunities. His veteran savvy and route-running precision make him a reliable option with significant upside potential.
Tre Tucker, Las Vegas Raiders (vs. Tennessee Titans)
Tucker has quietly emerged as one of fantasy football's most consistent performers, ranking as the WR16 in PPR scoring and WR10 in standard leagues through five weeks. He leads Las Vegas with four touchdowns and tops the team's pass-catchers with 315 scrimmage yards. Tennessee's defense has been particularly vulnerable to slot receivers, allowing the fifth-most receiving yards per game to the position. The Titans have permitted eight different opposing receivers to reach 67+ yards or score touchdowns, with three achieving both benchmarks. Tucker's role in Las Vegas's offense has grown consistently, and this matchup provides an excellent opportunity for continued production. His low roster percentage makes him an ideal tournament play with legitimate weekly starter potential.