The San Francisco 49ers were down one star with George Kittle out against the Chicago Bears. But now All-Pro left tackle Trent Williams is out too — following the game's first play with an injury.

ESPN 49ers insider Nick Wagoner discovered Williams heading into the blue tent. Austen Pleasants took over the blindside duties in his place amid the NFL injury. Williams is seen grimacing and walking off gingerly after the pick-six by TJ Edwards.

Williams has battled some notable injuries in recent years. Including dealing with a bone bruise early in San Francisco's season. He got ruled questionable for the rest of the night.

UPDATE: Williams has been ruled out for the remainder of the contest, according to Ian Rapoport of the NFL Network.

How 49ers fared after Trent Williams injury

San Francisco 49ers quarterback Brock Purdy (13) passes the ball against the Indianapolis Colts in the first quarter of the game at Lucas Oil Stadium.
© Trevor Ruszkowski-Imagn Images

Head coach Kyle Shanahan didn't deviate from the team's natural blueprint.

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He still turned to the famed ground-and-pound methods S.F. hits teams with. San Francisco hit the Bears with 83 rushing yards before the end of the first quarter. Even Brock Purdy called his own number and ran it up the left — also known as Williams' side.

Even Christian McCaffrey found wiggle run and turned the jets on for this 43-yard rumble — going up Pleasants' side.

San Francisco engaged in an early shootout with the Bears as both teams exchanged touchdowns. Purdy located a wide-open Jake Tonges for a one-yard touchdown. The Bears' Caleb Williams hit Luther Burden III for a 35-yard strike to tie the game up.

Given his status, Williams' availability for Week 18 is in limbo against the Seattle Seahawks — a 27-10 winner over the Carolina Panthers on Sunday. Seattle is positioned to seal the division and the top seed in the NFC with a win.