History is on the line for Novak Djokovic at this year's US Open and the stakes are higher than ever for the all-time great. Looking to win his 21st Grand Slam which would be the most in the history of men's tennis, Djokovic has a challenging road ahead of him. Now that there's a more level playing field at this year's US Open, the competition is as stiff as it's ever been and this will make for an exciting obstacle that Djokovic will have to overcome.
Especially if he wants to win it all and make history in the process of doing so. With a career milestone and history on the line for Djokovic, this will be the most exciting storyline at the tournament. Having said all this, let's take a look at the three best players who can upset Novak Djokovic at the 2021 US Open.
Alexander Zverev
Coming into this tournament as the number four ranked player in the world, Alexander Zverev definitely has a wild card mentality about him that could work to his advantage were he to go against Djokovic at this year's US Open tournament. His ability to aggressively attack the baseline paired with his endurance would give him the chance to force Djokovic into a five-set thriller and push him to the brink of elimination.
His crafty backhand and solid service game would be a challenge for Djokovic to counter. With his recent successes and expanding game, Zverev possesses the necessary skills and talent to overtake Djokovic at the US Open and ruin his chances of making history. If there's a player in this tournament who should not be overlooked, it's without question Alexander Zverev.
Daniil Medvedev
Currently ranked as the second-best player in the US Open, Daniil Medvedev would undoubtedly give Novak Djokovic a run for his money. He has previously shown that he has the talent and experience to pull off an upset and deny Djokovic of his 21st career major. With his powerful serve and backhand, he would give Djokovic a ton of trouble, especially during a series of long rallies.
His service returns and baseline dominance will also make things difficult for Djokovic and could give Medvedev an edge if he's able to either win the first couple of sets early on or force Djokovic into a five-set winner-take-all match. Either way, Daniil Medvedev definitely has a puncher's chance to pull off an upset and spoil Djokovic's opportunity to win another major.
Matteo Berrettini
After finishing as the runner-up at Wimbledon earlier this year, Matteo Berrettini will look to exact revenge against Novak Djokovic at this year's US Open. With his crisp serve and overpowering forehand, he has previously shown that he has the skills and strength to go the distance with the current world number one.
If Berrettini can utilize these attributes and expose more of Djokovic's weaknesses throughout the match, then he could definitely pull off a major upset at the US Open. This would also allow Berrettini to expand on his championship experience with his second straight appearance as a Grand Slam finalist.