The New Orleans Saints will hit the road in Week 16 as they take on the Tennessee Titans in an interconference matchup. The Saints come into this game following a historic performance from Drew Brees.

Last week against the Indianapolis Colts, Brees completed 29 of his 30 attempts for 309 yards and four touchdowns. On his third touchdown, Brees surpassed Peyton Manning for the most passing touchdowns in NFL history.

While it was impressive to see him leapfrog Manning's record, it might have been more impressive to see him break the single-game record for completion percentage. If it weren't for a slightly inaccurate pass to Latavius Murray in the second quarter, we are talking about Brees completing every pass he put in the air.

Nevertheless, New Orleans defeated the Colts 34-7 to improve to 11-3 on the season. Currently, the Saints have already clinched the NFC South and are positioned to have a first-round bye in the playoffs.

On the other hand, the Titans boast an 8-6 record and are hoping to keep their playoff hopes alive. A loss on Sunday versus the Saints would undoubtedly make it harder for Tennessee to play beyond December.

Provided that, here are four reasons why the Saints will defeat the Titans in Week 16.

4. The Saints have a pass rush to make Ryan Tannehill uncomfortable

While the Saints' defense has been wildly inconsistent, the one constant on their defense is their ability to get after the quarterback. Through the first 15 weeks, New Orleans has accumulated 44 sacks (fourth-most in the NFL).

Since becoming the starter, Ryan Tannehill has become one of the best starting quarterbacks in the NFL for the Titans. As good as he's been, Tannehill has been masterful when he's been given a clean pocket.

According to Player Profiler, Tannehill has completed 77.5 percent of his passes when throwing in a clean pocket. That number drops down to 51.8 percent when he has pressure in his face.

3. Alvin Kamara and Latavius Murray will have success on the ground

When the Saints signed Latavius Murray in the offseason, it was expected that he would see a minimal role behind Alvin Kamara. Contrary to belief, the two running backs have shared the workload—even when Kamara has been healthy.

The duo of Kamara and Murray has allowed the Saints to have the 16th ranked rushing offense in the NFL (108.6 yards per game). At the same time, Tennessee's run defense has shown that they can be taken advantage of in recent weeks.

Just last week, Carlos Hyde gashed the Titans' defense for 104 yards and a touchdown in the Houston Texans' victory of Tennessee. The 13th ranked run defense of the Titans is going to have trouble containing the rushing attack of the Saints on Sunday.

2. Drew Brees is heating up

Since returning from a thumb injury in Week 8, Drew Brees has been utterly dominant. The 40-year-old quarterback has completed 76.3 percent of his passes for 2,039 yards, 19 touchdowns, and two interceptions in his last seven starts.

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JC Latham (Alabama), Chris Braswell (Alabama not Jaguars), Cornelieus Johnson (Michigan) in action behind a New Orleans Saints logo with a 2024 NFL Draft background.

Dylan Bruton ·

In addition, Brees has shown that it doesn't matter what defense he faces; he's going to pick it apart and put the Saints in a position to win the game. Just two weeks ago, Brees lit up the San Francisco 49ers' No. 1 ranked pass defense for 349 yards and five scores.

This week, Brees will draw the 25th ranked pass defense of the Titans on the road. There's no reason to believe that Brees won't carve up a secondary that is decimated with injuries.

1. New Orleans has the run defense to slow down Derrick Henry

Even while Tannehill has been remarkable under center, everyone knows that the focal point of Tennessee's offense is Derrick Henry. The NFL's second-leading rusher has garnered 1,329 yards and 13 touchdowns on the ground.

Furthermore, Henry has rushed for over 100 yards and scored a touchdown in four out of his last five games. Luckily for the Saints, they have been stout against the run in 2019.

As a matter of fact, New Orleans has the fourth-best run defense in the NFL that allows 90.8 yards per game. With the Saints keeping Henry in check, the defense can make the Titans' offense one-dimensional.