The Cleveland Browns host the Seattle Seahawks for a big-time Week 6 tilt. While the Browns are coming off of a loss and are needing a win, the Seahawks are 4-1 and closing the gap on the lead for the NFC West. Though the Browns are desperate for a victory — at 2-3 — the Seahawks will get it.

Here are four reasons why.

4. Browns offensive line

The Browns can't protect Baker Mayfield. Their offensive line — without Kevin Zeitler (now in New York) — is a defeated unit and a deserving much-maligned one. Through five weeks of play, Mayfield has been sacked 16 times on the year. Per Pro Football Reference, the second-year quarterback has been hurried 29 times and has taken five hits.

Mayfield hasn't responded to pressure well. He leads the league in interceptions with eight. A fair amount of those have come with pressure. Though the Seattle Seahawks' pass-rush is hit-or-miss on the season, Jadeveon Clowney, Ezekiel Ansah, and Poona Ford could have a field day against a subpar line. In turn, Mayfield may struggle — again.

3. Russell Wilson

If Russell Wilson isn't your MVP pick, you're doing something wrong. Wilson doesn't just lead the NFL in passing touchdowns (12), he also hasn't thrown an interception and leads the league in adjusted yards gained per attempt (10.6). He can make those stats look better against a Browns defense that isn't exactly stout.

Though Cleveland's 1,032 passing yards allowed is an above-average number, their 10 passing touchdowns allowed is worrisome. That notion becomes truer, considering they are yet to face a quarterback of Wilson's caliber in 2019. Though cornerbacks Denzel Ward and Greedy Williams may be back on Sunday, don't expect the Browns defense — and subsequently secondary — to have many answers for Wilson.

2. The rest factor

The last time the Browns played, it was Monday Night Football. They left San Francisco in defeat, losing 31-3 to the 49ers. Meaning, they have a six-day rest to rebound from their blowout loss and go home to hope to save their season. On the other hand, the Seahawks are well-rested and coming off of a win.

It's been a while since Seattle last played. Precisely, there will be a 10-day difference between Sunday's game and their Thursday Night Football win over the Los Angeles Rams. Though there is a four-day difference between the two last playing, that makes a big difference. Seattle is well-rested. The Browns are on a short week.

1. Rush defense

The Browns have not been able to get anything going through the air, despite boasting Odell Beckham and Jarvis Landry. However, where they have been successful is the ground. Second-year back Nick Chubb has looked the part of a bell-cow, rushing for 485 yards and four touchdowns on 94 attempts on the season.

Unfortunately for Cleveland, relying on Chubb against Seattle will be tough. The Seahawks run defense is one of the best in the NFL. Through five weeks, they are fifth in the NFL in rushing yards allowed (307), while also allowing four touchdowns. Considering how weak the Browns offensive line is and how talented the Seahawks run defense is, Chubb may not have another big day on Sunday.