The Arizona Cardinals will play the Dallas Cowboys in an NFC matchup in Week 17. It's time continue our NFL odds series with a Cardinals-Cowboys prediction and pick.

The Cardinals and Cowboys will play on Sunday in what is a huge game for both sides. Arizona has lost three straight after a 10-2 start and will need a win in this one if they want a chance to win the NFC West. Dallas has clinched the NFC East but is looking to run down the Green Bay Packers for the No. 1 overall seed in the NFC and home-field advantage throughout the postseason. The Cowboys come in as fairly big favorites over the Cardinals in this one as they have been hot of late.

Here is how FanDuel has set the Cardinals-Cowboys odds for this Week 17 NFL matchup.

NFL Odds: Cardinals-Cowboys Odds

Arizona Cardinals +5.5 (-110)

Dallas Cowboys -5.5 (-110)

Over 51.5 (-110)

Under 51.5 (-110)

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Why The Cardinals Could Cover The Spread

Arizona will again be without De'Andre Hopkins, so they will need Christian Kirk, AJ Green and others to step up and help Kyler Murray. Running backs James Connor and Chase Edmonds are also banged up, but it looks like at least one of them will be able to go*** CHECK THIS BEFORE PUB**. The Cardinals have not been the same team in the second half of the season as injuries and just overall poor play have them limping down the stretch into the postseason.

Arizona vs. the spread
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The Cardinals are 9-6 against the spread so far this season and 5-0 as underdogs. Arizona is 7-1 vs. the spread as the road team with the lone loss being their egg of a performance in their loss to the Detroit Lions a couple of weeks ago. The Cardinals have not covered since Dec. 5 when they won at home vs. the Chicago Bears.

Why The Cowboys Could Cover The Spread

Dallas has been on fire of late as they have gotten healthier over the past few weeks. They put on an offensive clinic in their Week 16 win over the Washington Football Team. The Cowboys look to be hitting their stride at the right time as their defense continues to excel as well. Dallas still has a shot at the No. 1 seed in the NFC so a win on Sunday will be huge in their efforts to secure home games throughout the postseason. This should be another good spot for a cover and a win vs. a struggling Arizona team that has been heading the wrong direction.

Dallas vs. the spread

The Cowboys are an impeccable 12-3 vs. the spread this season and have covered in four straight (and seven of their last ten for good measure). Dallas is 5-2 against the spread as home favorites this season and 9-2 as favorites overall. This could be a nice spot for Dallas to make their ATS record even more impressive.

Final Cardinals-Cowboys Prediction and Pick

Take the Cowboys to win and cover over the Cardinals in this one. Arizona seems to be falling apart while Dallas has been surging. The NFL can be unpredictable, but it's too hard to fade the Cowboys in this spot with how well they have been playing of late. Put your money on America's Team to win and cover vs. a reeling Cardinals group in Week 17.

Final Cardinals-Cowboys Prediction & Pick: Cowboys -5.5 (-110)