The Cleveland Browns' Week 6 tilt will certainly be a tough one as they host the undefeated Arizona Cardinals on Sunday afternoon. The matchup between the two stacked teams led by Baker Mayfield and Kyler Murray will definitely make the Browns-Cardinals tilt an exciting matchup for everyone.

Heading to the game, Arizona will be without a few injured players on their roster which will make it easier for Cleveland to try and grab a win at their expense. However, Kevin Stefanski will also need to ensure that his men will execute their schemes and play at their best, especially when they take the field against an undefeated opponent in the Cardinals.

Here are four predictions for the Cleveland Browns' Week 6 tilt against the Cardinals:

Cleveland Browns Week 6 Predictions

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4. The ClevelandBrowns' defense led by Myles Garrett will show out against the Cardinals.

Cleveland's defensive unit failed to play its A-game against the Los Angeles Chargers as they allowed their opponents to score 47 points last week. Myles Garrett only tallied two tackles but he did record a sack against Justin Herbert, thus increasing his sack total to seven to lead the league as of Week 5.

In Week 6, the star pass-rusher will have to go up against a much-improved offensive line that has been doing a solid job of protecting Murray in the pocket. After a subpar game, Garret will definitely be eager to bounce back and lead the Browns' defense to successfully contain their opponents in Week 6.

3. Kareem Hunt will lead the ground game and tally at least 100 rushing yards.

The Cleveland Browns are set to miss the services of RB1 Nick Chubb in their game against the Cardinals as he suffered a calf injury last week. The two-time Pro Bowler had a monster game against the Chargers as he notched 161 yards on 21 carries to go with a rushing TD scored.

With Chubb's absence, the Browns will now entrust the running game to another prolific threat in Kareem Hunt. He also had a stellar outing in Week 5 as he recorded 61 yards on 12 attempts to go with a couple of scoring drives for the Browns.

Kevin Stefanski will still utilize the ground game even with Chubb's absence and Hunt will have to put up points across the board in order to give a major advantage to his team against the Cardinals.

2. Baker Mayfield will throw at least 250 passing yards and two touchdowns.

Chubb's absence will also affect the Browns' offensive attack as they are expected to utilize the passing game more, as compared to their previous games. In addition, the Cardinals' secondary depth is still depleted as cornerbacks Byron Murphy Jr. and Marco Wilson are both listed as questionable for Week 6 due to similar rib injuries.

If both defenders fail to suit up this weekend then the Browns will surely capitalize on their absence and will throw the ball down the field. With this, Browns fans can expect to see more from David Njoku, Odell Beckham Jr., Rashard Higgins, and Donovan Peoples-Jones as they try to step up and contribute more to the scoring department.

If they all manage to deliver on the field then it won't be hard for Baker Mayfield to reach at least 250 passing yards and throw a couple of touchdowns against the Cardinals.

1. The Cleveland Browns will secure a tight victory and hand the Cardinals their first loss of the season.

Heading to Week 6, Arizona doesn't have a completely healthy squad as Kyler Murray was limited in practice due to a shoulder injury while DeAndre Hopkins just recovered from an illness over the past week. Linebacker Chandler Jones and center Rodney Hudson are also expected to miss their Week 6 tilt due to various reasons.

Still, the Cardinals remain to be a dangerous team even without a healthy lineup. The Browns will surely be in for a tough matchup but they have the tools to secure an upset victory and send their opponents home with a loss for the first time this season.

If they manage to do so then it will surely serve as a confidence-boosting win as they can improve to a 4-2 record and potentially vie for the top spot in the AFC North.