New York Giants running back Isaiah Crowell is coming off the best game of his career. Unfortunately, it came with a bit of a price after sustaining an ankle injury.

Crowell's status has been up in the air all week. According to ESPN's Rich Cimini, he will be a game-time decision versus the Indianapolis Colts in Week 6:

Jets final injury report: Isaiah Crowell will be a game-day decision, according to coach Todd Bowles. Best bet: Crowell plays. They will be without CB1 (Trumaine Johnson) and CB3 (Buster Skrine), meaning bigger roles for Darryl Roberts, Parry Nickerson and perhaps Rashard Robinson.

Crowell's lingering status is concerning for New York's offense. He is coming off a historic day versus the Denver Broncos after finishing with a franchise-record 219 yards. The veteran now leads the AFC Conference with 290 yards on the season. Unfortunately, he may not have a chance to maintain his lead given his lingering status.

It is no secret that the Jets are at their best when they establish a strong ground game. Crowell was heavily featured in both of their landslide victories this season. The run game not only allows them to dominate the time of possession but it also takes pressure off of rookie quarterback Sam Darnold.

The Jets backfield has an ideal matchup against a generous Colts defense in Week 6. However, they may have to resort to a committee if Crowell is unable to suit up. Running back Bilal Powell is the most likely candidate to receive the bulk of the carries.