Atletico Madrid will be hosting Real Madrid at their Wanda Metropolitano in the Madrileno, one of the biggest derbies in Spanish football. With that said, it’s a good time to check out our La Liga odds series, which includes our Atletico-Real Madrid prediction and pick we have laid out below.

Atletico Madrid are in a massive fight to hold on to Champions League football. They were one of the title challengers for most of the season, but an abysmal spell in December paired up with some losses along the way means that Atleti will need some massive wins to end the year in the top four. Real Madrid, on the other hand, enters this game as possibly the team with the most confidence in the world. They secured the title last Saturday and eliminated Manchester City with two late goals by Rodrygo and an extra-time penalty by Karim Benzema. Now, they have a chance to land a massive blow on their crosstown rivals' hopes to play in the Champions League next season.

Courtesy of FanDuel, here are the Atletico-Real Madrid La Liga odds:

La Liga Odds: Atletico-Real Madrid Odds

Atletico: (+110)

Real Madrid: (+270)

Draw: (+230)

Over: 2.5 (-102)

Under: 2.5 (-118)

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Why Atletico Could Win This Match 

Atletico Madrid looked like a team set to fight for a title in the first few months of the season but slipped up recently. Despite these slip-ups and a very tough exit in the Champions League, Atletico can still make this season successful and it starts in the Madrileno. Their players know what they are fighting for and while they did lose their last La Liga game, Atleti can make it all better by securing a win in this game.

The first game played at the Santiago Bernabeu in December was a 2-0 Real Madrid win, but it will be a different Real Madrid squad in this game. With the title in their hands and players that just played 120 minutes mid-week, Atletico will be boasting their best team versus, likely, the B-team of Real Madrid. That is where the biggest chance for Los Colchoneros is coming from.

Additionally, the recent form and overall place on the table are not representative of the true strength of their squad. Atletico Madrid have some great players, including the likes of Antoine Griezmann, Luis Suarez, Angel Correa, and Joao Felix. They definitely have the personnel to win this affair and not only get one on their rivals but also get a massive boost for their fight to secure Champions League football next season.

Why Real Madrid Could Win This Match 

If there is a team in form at the moment in the entire world, it is Real Madrid. Los Blancos secured their 35th La Liga title on the weekend, playing their second lineup versus Espanyol and securing a 4-0 win. As great as that is, the greatest moment of the season, barring a win in the Champions League final, was their incredible comeback against Manchester City, with Rodrygo scoring two goals in two minutes and Karim Benzema adding the third in extra-time to win the entire tie for the 13-time winners of the competition.

With 120 minutes of football on Wednesday and with nothing to play for in the league, common logic would suggest that Real Madrid do not have much of a chance in this game. Yet, this is the Madrileno and all logic goes out of the window in derbies. It will be a game where many will have a chance to show off their talent, but also a game in which Real Madrid could deal a knock0ut punch to their rivals.

Additionally, Atletico players refused to give Real Madrid the guard of honor, which could be another motivating factor for Los Blancos. Of course, it will be a lot tougher to win without the services of many first-team players, as they are expected to rest, but a derby is a derby and after losing 4-0 earlier in the season to Barcelona, a negative result could have consequences for Real Madrid, even if it means nothing in terms of points on the table.

Final Atletico-Real Madrid Prediction and Pick 

Not unlike any derby in the world, this one is incredibly difficult to predict. Atletico will be at home with their best eleven, but Real Madrid are just beaming with confidence and could stop the path of Atletico towards the top four. Due to the incredible form they are currently in, our final Atletico-Real Madrid prediction will be a Real Madrid win at the Wanda Metropolitano.

Final Atletico-Real Madrid Pick: Real Madrid (+270)