The 6-2 New Orleans Saints will host the 4-5 San Francisco 49ers in Week 10 at the Mercedes-Benz Superdome. New Orleans is heavily favored to win this game for a variety of reasons.

In Week 9, the Saints demolished the Tampa Bay Buccaneers by a final score of 38-3. Drew Brees outplayed Tom Brady by throwing four touchdown passes. Brady, meanwhile, was sacked three times and threw three interceptions. New Orleans' defense didn't allow the Buccaneers to score a touchdown and dominated the game from start to finish on Sunday Night Football.

The 49ers, meanwhile, fell to the Green Bay Packers in Week 9. The team is decimated by injuries right now, as Jimmy Garoppolo, Nick Bosa, George Kittle, Deebo Samuel, Raheem Mostert and Richard Sherman are all out. This isn't the same 49ers team that won the NFC last season and played in the Super Bowl against the Kansas City Chiefs.

With the Saints-49ers game almost here, let's take a look at four bold predictions for the contest from a New Orleans point of view.

1. Drew Brees throws four touchdowns

New Orleans Saints, Drew Brees

Brees continues to play at a high level for the Saints despite being 41-years-old. He's thrown 17 touchdowns on the season and racked up 2,120 passing yards while completing 74.0 percent of his passes.

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Against the 49ers, we have Bress throwing for four touchdowns, just like he did in Week 9 against the Buccaneers. San Francisco got torched by Packers superstar quarterback Aaron Rodgers in Week 9, so odds are Brees will follow suit.

Even though his arm strength isn't what it used to be, Brees is still pushing the ball down the field effectively. The Saints have the ninth-best passing attack in the NFL with Brees leading the way. We have the future Hall of Famer continuing his stellar play against the 49ers in New Orleans in Week 10.

2. Michael Thomas catches two touchdowns

Saints star wideout Michael Thomas made his return to the lineup in Week 9 against the Buccaneers. He caught five balls on six targets for 51 yards and didn't look rusty at all.

Against the 49ers, we have Thomas catching two touchdowns from Brees and reminding everyone who the best wide receiver in the NFL is. His uncle, former NFL star Keyshawn Johnson, has been harping on the fact that Thomas is still the best player at his position despite the superb seasons DeAndre Hopkins, Julio Jones, Davante Adams and DK Metcalf are having for their respective teams.

Week 10 against the 49ers is the perfect game for Thomas to showcase his elite skills and go off for the first time in 2020. He's faced the 49ers twice before and had monster performances.

Thomas has 16 receptions in two games against the Niners for 207 yards and three touchdowns.

3. Alvin Kamara records 100 yards from scrimmage

New Orleans Saints

Arguably the most versatile playmaker in the NFL, Alvin Kamara has racked up 1,036 yards from scrimmage already this season. The Saints' do-it-all running back has 471 rushing yards and 565 receiving yards.

Against the 49ers, we have Kamara recording 100 yards from scrimmage. He's too quick in the open field for San Francisco's linebackers to keep up with, so don't be surprised if Kamara has some huge chunk plays both in the running and passing game.

Kamara has only faced the 49ers once in his career. He finished the 2019 game with 43 yards from scrimmage, so look for the Pro Bowler to play with a chip on his shoulder in Week 10 and have an astounding game for the Saints.

4. Saints defeat 49ers to improve to 7-2

Entering Week 10, the Saints are tied with the Seattle Seahawks and Packers for the best record in the NFC at 6-2. This team looks primed to go on a Super Bowl run with Brees, Kamara and head coach Sean Payton leading the way.

With that being said, we don't see New Orleans losing to the 49ers. The club is on a hot streak right now and coming off a statement win over the Buccaneers in Week 9 on the road.

Since Brees is getting up there in age, this season could be the last year the Saints can make a Super Bowl run with the former Purdue Boilermaker. The team can't waste this special season he's having and must do everything in its power to clinch the No. 1 seed in the NFC.

A win against the 49ers will inch the Saints closer to that goal. We just can't see a Payton-coached team taking its foot off the gas pedal against a struggling 49ers squad. Look for the Saints to improve to 7-2 and continue their strong play on both sides of the ball.