Looking to bounce back from a brutal loss to the Philadelphia Eagles in Week 11, the New Orleans Saints will have their hands full with a Buffalo Bills team who will be fighting to avenge a tough loss of their own. With a slew of changes in the fold for New Orleans, it would be an understatement to say that this season has been an uphill battle for Sean Payton and the Saints.

As they continue to battle through adversity and overcome a series of challenges, the Saints will be looking to make things tough for the Bills during their Thanksgiving day match-up.

For more insight on the Saints' Week 12 matchup against the Bills on Thanksgiving, listen below:

Aiming to stay in the playoff mix and come up with a quality win against the Bills, let's look at our Saints Week 12 predictions.

New Orleans Saints Week 12 Predictions

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4. Trevor Siemian will have a productive day for the Saints 

After throwing a few costly picks last weekend against the Eagles, Trevor Siemian is primed to have a big game for the Saints on Thanksgiving day. With a multi-skilled offensive unit and versatile game plan in the fold for New Orleans, Siemian will be set-up nicely to thrive under center for the Saints in Week 12.

In their effort to turn things around and hold second place in the NFC South, the Saints will need a strong performance from Siemian as they hope to avoid another tough loss and slipping into third place in the division. While they still work to figure things out on offense and find some consistency, Siemian finds himself in good position to have a big game for the Saints.

3. Mark Ingram and Tre'Quan Smith will set the tone for them on offense 

As two of the Saints best offensive players, Mark Ingram and Tre'Quan Smith are vital to their game plan and will need to bring their all against the Bills on Thursday. With so many moving pieces in the Saints offense, they'll definitely need Ingram and Smith to step up their games once again and set the tone for them on offense in Week 12.

If one thing's true, it's that the Saints offense is a resilient bunch and can run with the best of them. Ingram and Smith will intend to dish out some serious damage against the Bills struggling defense and snap out of their current funk. So come Thursday night, watch out for Ingram and Smith to set the tone for the Saints offense while filling out the stat sheet.

2. Marshon Lattimore and Cameron Jordan will lead the charge for them on defense

Coming off a quiet day against the Eagles last weekend, Marshon Lattimore and Cameron Jordan will both need to bring their A-game against the Bills on Thursday as they hope to avoid another blowout loss to Buffalo. It's proven that the Saints defense plays a way more efficient style of football when Lattimore and Jordan are playing at their absolute best, and with the current state their team is in, a dominant showing from these two Pro Bowl caliber defensive talents is highly likely for the Saints on Thursday night.

1. New Orleans will suffer another tough loss at the hands of Buffalo 

Even with all the adjustments they'll have made and a ton of talent on both sides of the ball for them, the New Orleans Saints have been horribly inconsistent since they lost Jameis Winston to a season-ending ACL injury. They have come up with a few surprising victories, but going against a Bills team that has their backs against the wall will be a different story.

Plus with the youth and athleticism that team possesses, it's safe to assume that the Bills will be playing desperate and ready to overcome whatever the Saints throw their way on Thursday night. Despite their most valiant efforts, the Saints will fall short once again and run the risk of losing their spot at second place in the NFC South.