San Francisco 49ers star tight end George Kittle was ruled out of the forthcoming Week 2 matchup with the New York Jets, according to NFL Network's Tom Pelissero.

Kittle, 26, has been the premier pass-catching and blocking tight ends in the NFL since his arrival on the scene back in 2017, becoming a two-time Pro Bowler in the past two seasons while hooking up with 49ers quarterback Jimmy Garoppolo.

The former fifth-round selection out of Iowa signed a massive contract extension with the 49ers in the offseason, agreeing to stay in the Bay Area over the next five years for $75 million. Kittle's long-term deal with the NFC West club came hours before tight end peer Travis Kelce agreed to a comparable extension with the defending champion Kansas City Chiefs over four years.

Kittle injured his knee during the 49ers' Week 1 tilt with the Arizona Cardinals on a collision with safety Budda Baker. Earlier today the 49ers called Kittle a game-time decision (but he's ruled out even though game time is Sunday). Baker became the victim of hateful messages on social media after the incident, which the 49ers later condemned.

Both the 49ers and Jets are 0-1 on the season following Week 1 defeats.

The 49ers, besides Kittle, are low on pass-catchers entering just the second Week of the 2020 NFL regular season, as rookie wide receiver Brandon Aiyuk missed Week 1 and rising star sophomore wideout Deebo Samuel is on the injured reserve (IR) list coming off of a foot fracture. Despite suffering that knee sprain against the Cardinals, Kittle still registered four catches on five targets for 44 yards.