Oklahoma will take on Kansas State in what is an important Big 12 game in college football this weekend. It's time to continue our College Football odds series and make an Oklahoma-Kansas State prediction and pick.

Oklahoma comes into play on Saturday undefeated at 4-0, but hasn't looked as good as people expected coming into the season. Kansas State is 3-1, with their lone loss of the season coming last week on the road vs. Oklahoma State. The Sooners are 1-3 ATS this season, while Kansas State is 2-2 vs. the spread in 2021. Oklahoma has had close calls vs. Nebraska, West Virginia and Tulane already and they are on upset alert with this road conference matchup.

Here's how the bookmakers have set the Oklahoma- Kansas State odds for Saturday's matchup.

College Football Odds: Baylor-Oklahoma State Odds

Oklahoma -12 (-110)

Kansas State +12 (-110)

Over 52.5 points (-110)

Under 52.5 points (-110)

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Why Oklahoma Could Cover The Spread

Oklahoma has the most talent in all of the Big 12, or at least they are supposed to. Quarterback Spencer Rattler has not lived up to his Heisman Trophy type expectations so far, while the Sooner defense has been inconsistent as well, though they have looked solid the past two weeks. Oklahoma has held opponents to 79 rushing yards per game this season, and Kansas State relies on their rushing attack quite heavily. Over half of the Wildcats offense derives from the run game, so if the Sooners can limit their ground attack they may be in good shape to cover on Saturday afternoon. Kansas State quarterback Skylar Thompson is also unlikely to play due to a knee injury.

Why Kansas State Could Cover The Spread

So far, everyone other than Western Carolina has covered vs. Oklahoma this season. The Wildcats have played Oklahoma close in recent seasons, beating them the last two seasons. It may be an uphill battle if Thompson is unable to suit up for Kansas State, but perhaps the line is inflated because of his potential absence. The Wildcats will also be on their home field for the Big 12 matchup, something that is always a key factor to consider in what will be perhaps the biggest game of the season for the home team.

Final Oklahoma-Kansas State Prediction & Pick

It is hard to rely on the Sooners to cover 12 points on the road when they haven't covered a spread vs. a Power 5 opponent so far in 2021. Even if Thompson is unable to go for Kansas State, take the points and the homefield advantage come Saturday. Given that Kansas State relies on the run game, they may be able to generate offense even without their starting signal caller. If the Wildcats defense can get a few stops, they may be able to score enough points to cover.

FINAL OKLAHOMA-KANSAS STATE PREDICTION & PICK : Kansas State +12 (-110)