The Milwaukee Bucks and Philadelphia 76ers will play in an Eastern Conference matchup on Tuesday night. It's time to continue our NBA odds series and make a Bucks-76ers prediction and pick.

The Bucks and 76ers both enter play on Tuesday with some notable absences. Philadelphia is battling COVID issues, as Tobias Harris and Joel Embiid have entered the protocol. The 76ers are obviously also still without Ben Simmons. Milwaukee is still missing Khris Middleton and Brook Lopez, but they will have their MVP Giannis Antetokounmpo and a rest advantage on Tuesday. The Bucks enter play as strong favorites over the 76ers, as they have both a roster and rest advantage with the 76ers having played on Monday.

Here's how bookmakers have set the Bucks-76ers odds for this Tuesday night matchup.

NBA Odds: Bucks-76ers Odds

Milwaukee Bucks -5.5 (-110)

Philadelphia 76ers +5.5 (-11o)

Over 217.5 points (-110)

Under 217.5 points (-110)

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Why The Bucks Can Cover The Spread

The Bucks should have a clear talent edge. Middleton and Lopez are listed as out but they are healthy otherwise. Antetokounmpo provides a huge edge vs. a Sixers team that is without their best three players now that Embiid is in the protocol. The Bucks rank just 19th in the NBA with a -1.7 net rating, but they have also yet to have their full team for any extended stretch. Antetokounmpo and Jrue Holiday should put the Bucks in good position to cover and win vs. short-handed 76ers team that is also on a back-to-back. Milwaukee has lost four of their last five, so they will be desperate for a win in this spot vs. a short-handed Philadelphia team.

Why The 76ers Can Cover The Spread

The 76ers face an uphill battle Tuesday. Despite all of their issues this year, Philadelphia still ranks fourth in the NBA in net rating and has looked pretty good. Their 8-3 record is evidence of this, and likely keeping them from being a bigger underdog in this spot. The 76ers will not be the same team on Tuesday though, as they will be without their star center Joel Embiid in addition to others. They will need guys like Seth Curry and Tyrese Maxey to step up more than ever if they are going to have any chance to cover and win vs. the Bucks on Tuesday. After losing to the New York Knicks on Monday, the 76ers are both short-handed and on a back-to-back when they face Milwaukee on Tuesday night.

Final Bucks-76ers Prediction & Pick

Take the Bucks to cover and win vs. the 76ers on Tuesday night. The absences are mounting for Philadelphia, and the Bucks badly need a win.

FINAL BUCKS-76ERS PREDICTION & PICK: Bucks -5.5 (-110)