Now that Carson Wentz will be a game-time decision for the Indianapolis Colts after injuring both ankles last weekend against the Rams, there's a cloud of uncertainty surrounding their quarterback situation heading into their Week 3 match-up against the Titans. Aside from this unfortunate occurrence, the Colts are also seeking their first win of the season.

After a close loss to the Rams last weekend and a poor showing against the Seahawks in Week 1, the Colts are in dire need of a win that'll keep them competitive in the AFC South and boost their team morale. With all this in the fold for Indianapolis, let's take a look at four bold predictions for their Week 3 match-up against the Titans.

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4. The Colts will alternate quarterbacks on Sunday 

With Carson Wentz now set to be a game-time decision, Colts head coach Frank Reich will more than likely alternate between both Jacob Eason and Brett Hundley throughout the game. This will give the Colts two different approaches on offense and allow Reich to see if the offense is more productive with Eason or Hundley under center for them.

Hoping to get some consistency at the quarterback spot, the Colts will be doing some experimenting at the position this Sunday during a crucial match-up against their division rivals. Still in search of their first win this season, the Colts are also looking for a permanent solution at quarterback that can keep them competitive during their 2021 campaign.

3. Marlon Mack and Mo Alie-Cox will put up big numbers for the Colts 

As two of their best assets on offense, Marlon Mack and Mo Alie-Cox were both non-factors for the Colts last weekend. This could be due to Wentz getting injured and both of them not having the same team chemistry with Eason, but they will need to step up on offense for the Colts in a major way this Sunday if they want to avoid their third straight loss of the season.

Between the speed, strength, and steady hands of these two offensive talents, the Colts will need to find a way to get them more involved in their offensive game plan against the Titans this Sunday. It will be of utter importance for Mack and Alie-Cox to put on big performances this Sunday as the Colts season could slowly start to slip away. Desperate for their first win of the season, it can definitely be expected that Marlon Mack and Mo Alie-Cox will put up big numbers for the Colts in Week 3.

2. Indianapolis won't be able to stop Derrick Henry 

Considering how he effortlessly ran all over the Seahawks last weekend, there's no doubt that he'll be able to repeat this success against the Colts on Sunday. Primed for another big game in Week 3, Derrick Henry will be ready to run all over the Colts defense and make tomorrow afternoon's match-up a living nightmare for the Colts.

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GM Ran Carthon in the middle, Joe Alt, Adisa Isaac, Jamari Thrash around him, and Tennessee Titans wallpaper in the background

Enzo Flojo ·

GM Chris Ballard in the middle, Jared Verse, Troy Franklin, Jaden Hicks around him, and Indianapolis Colts wallpaper in the background

Enzo Flojo ·

With Henry being arguably the toughest player to tackle in the open field, the Colts are going to have all kinds of headaches while trying to find a way to slow him down on Sunday. Now that Henry is getting hot at the right time for Tennessee, the Colts will be in trouble as their defense will be victims of another dominant performance by Derrick Henry tomorrow afternoon.

1. Indianapolis will lose its third straight game 

In spite of their best efforts, the Colts will not be able to keep pace with this explosive Titans team that's starting to find their groove after an epic comeback win last weekend. Henry, Ryan Tannehill, Julio Jones, and AJ Brown will give the Colts all kinds of trouble as the Titans will look to come away with a big win in Week 3.

Hoping to come away with their second straight win, the Titans will be firing on all cylinders and be picking apart the Colts defense all game long. Now that the Colts have a conundrum at the quarterback position, this will likely disrupt their offense and put more pressure on their defense to come up with big plays. With a series of problems at the helm for Indianapolis, they'll more than likely be overwhelmed by the Titans on Sunday and be dealt their third straight loss of the season.