The Indianapolis Colts will take on the Cleveland Browns in Week 5 in a matchup of two 3-1 teams. The Colts are coming off an impressive road win in Week 4 against the Chicago Bears, while the Browns took care of business on the road as well versus the Dallas Cowboys.

The Colts are favored to defeat the Browns since they have arguably the best defense in the NFL and their offense is starting to get things going as well in Philip Rivers' first season with the club.

With that being said, ClutchPoints has made four bold predictions for the game.

1. The Colts will pick off Baker Mayfield two times

The Colts have the No. 1 scoring defense in the NFL at the moment, as they are giving up only 14.0 points per game. While the Browns are scoring 31.0 points per game through their first four contests, Baker Mayfield is about to face his stiffest test of the season.

Mayfield has thrown for seven touchdowns and just two interceptions on the season. He's also completing 62.6 percent of his passes for 729 yards. Browns fans are excited that their favorite football team may finally have a quarterback, but things may be rough for the Heisman Trophy winner in Week 5 against the Colts.

The Colts already have seven interceptions on the season. Their elite pass rush has been getting to opposing quarterbacks at a high rate and it's allowing Indianapolis' secondary to pounce on some errant throws.

Mayfield has a tendency to be erratic in the pocket when he's under pressure, so look for him to make a few mistakes against Matt Eberflus' defense.

2. Philip Rivers will throw for three touchdowns

Through his first four games as a member of the Colts after a stellar career with the Los Angeles Chargers, Philip Rivers has thrown for 984 yards and four touchdowns. He's also completing 72.7 percent of his passes and is starting to develop a nice rapport with his receivers.

The Browns have one of the worst defenses in the NFL. They are giving up 31.5 points per game and almost choked the game away in Week 4 against the Cowboys. Look for Rivers and the Colts' offense to rack up a ton of yards through the air against the Browns. Tight end Mo Alie-Cox should be able to find the end zone again and T.Y. Hilton could score on a long bomb from Rivers since the Browns' secondary is pretty suspect.

While Rivers has thrown three interceptions on the season and could throw one against the Browns since he's such an aggressive-minded quarterback, odds are the future Hall of Famer will have his way versus the Browns and throw for three touchdowns in a Colts win.

3. Jonathan Taylor will rush for 100-plus yards

Colts rookie running back Jonathan Taylor hasn't looked like a rookie in his first four NFL games. He's carried the ball 65 times for 250 yards and two touchdowns.

As we already mentioned, the Browns have a putrid pass defense, but their run defense is pretty solid, as they are only allowing 91 rushing yards per game.

However, look for Taylor and the Colts' rushing attack to go off against the Browns in Week 5. Indianapolis is averaging 115 rushing yards per game, which is good for 15th in the NFL. The more and more comfortable Taylor gets running behind his offensive line, the more lethal the Colts' rushing attack is going to get.

The Browns are 3-1 for the first time in what seems like forever. The franchise isn't used to winning games like this, particularly early on in the season. Since they are coming off an exciting win over the Cowboys in Week 4, the team could face a hangover of some sorts in Week 5 and allow Taylor and the Colts running game to just run all over them.

4. Colts defeat Browns to improve to 4-1

The Colts lost their opening game of the season to the Jacksonville Jaguars, but have since defeated the Minnesota Vikings, New York Jets and Bears. The team is in a nice groove at the moment and should be able to go into Cleveland and defeat the Browns since they have the better head coach, quarterback and defense.

The AFC South Division is going to come down between the Colts and Tennessee Titans since the Jaguars and Houston Texans aren't competitive. Indianapolis has to win games they are favored in this season since it looks like the Titans' miracle run in 2019 wasn't a fluke.

With a veteran quarterback and smart head coach leading the way, the Colts are in a great position to defeat the Browns in Week 5 to improve to an impressive 4-1 on the 2020 season.